MODULAR CONSTRUCTION OF LIPOPHOSPHOLIPIDS

Abstract : The present invention relates to fluorescent and/or targeting lipophilic compounds having the general formula (R1O) (R2O) P (O) - R3 - R4 - R5 wherein R1 and R2 are each independently a linear or branched, saturated or unsaturated C2-C24 alkyl, or a linear or branched, saturated or unsaturated C2-C24 monoalkenyl or polyalkenyl, the polyalkenyl having from 2 to 4 double bonds, or a linear or branched, saturated or unsaturated C2-C24 monoalkinyl or polyalkinyl, the polyalkinyl having from 2 to 4 triple bonds; R3 is selected from 0, S, -C(R6)2-, -CH(R7)-, -C(S) -N(R6) -, - CH ( SR7 ) - S - S - or -N(R6)- wherein R6 is a hydrogen atom or a C1 - C4 alkyl, and R7 is a C1 - C4 alkyl; R4 comprises at least one junction function and at least one linker; and R5 is at least one chemical fluorescent group or at least one targeting group. Methods for preparing said lipophilic compounds are also disclosed.
Type de document :
Brevet
France, Patent n° : WO 2012004419 A2. 2012
Domaine :
Liste complète des métadonnées

http://hal.univ-brest.fr/hal-01620524
Contributeur : Nicolas Renard <>
Soumis le : vendredi 20 octobre 2017 - 16:28:33
Dernière modification le : jeudi 11 janvier 2018 - 06:17:07

Identifiants

  • HAL Id : hal-01620524, version 1

Collections

Citation

Jean-Pierre Haelters, Mathieu Berchel, Hélène Couthon, Paul-Alain Jaffres. MODULAR CONSTRUCTION OF LIPOPHOSPHOLIPIDS. France, Patent n° : WO 2012004419 A2. 2012. 〈hal-01620524〉

Partager

Métriques

Consultations de la notice

42