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MODULAR CONSTRUCTION OF LIPOPHOSPHOLIPIDS

Abstract : The present invention relates to fluorescent and/or targeting lipophilic compounds having the general formula (R1O) (R2O) P (O) - R3 - R4 - R5 wherein R1 and R2 are each independently a linear or branched, saturated or unsaturated C2-C24 alkyl, or a linear or branched, saturated or unsaturated C2-C24 monoalkenyl or polyalkenyl, the polyalkenyl having from 2 to 4 double bonds, or a linear or branched, saturated or unsaturated C2-C24 monoalkinyl or polyalkinyl, the polyalkinyl having from 2 to 4 triple bonds; R3 is selected from 0, S, -C(R6)2-, -CH(R7)-, -C(S) -N(R6) -, - CH ( SR7 ) - S - S - or -N(R6)- wherein R6 is a hydrogen atom or a C1 - C4 alkyl, and R7 is a C1 - C4 alkyl; R4 comprises at least one junction function and at least one linker; and R5 is at least one chemical fluorescent group or at least one targeting group. Methods for preparing said lipophilic compounds are also disclosed.
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https://hal.univ-brest.fr/hal-01620524
Contributor : Nicolas Renard <>
Submitted on : Friday, October 20, 2017 - 4:28:33 PM
Last modification on : Thursday, November 29, 2018 - 4:09:19 PM

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  • HAL Id : hal-01620524, version 1

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Citation

Jean-Pierre Haelters, Mathieu Berchel, Hélène Couthon, Paul-Alain Jaffres. MODULAR CONSTRUCTION OF LIPOPHOSPHOLIPIDS. France, Patent n° : WO 2012004419 A2. 2012. ⟨hal-01620524⟩

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