Fish oil attenuates adrenergic overactivity without altering glucose metabolism during an oral glucose load in haemodialysis patients

Jacques Delarue 1 Marie-Paule Guillodo 2 Sophie Guillerm 1 Anthony Elbaz 3 Yanic Marty 3 Jacques Clèdes 2
1 Dep Nutrition - BREST - Département de Nutrition
2 Association pour l'Aide aux Urémiques chroniques de Bretagne
3 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
Abstract : Haemodialysis patients display an increased cardiac mortality, which may be partly related to increased sympathoadrenal activity and insulin resistance. Fish oil decreases adrenal activation induced by mental stress and has an insulin sensitizing effect in healthy subjects. Whole-body glucose metabolism after oral glucose was studied in eight haemodialysis patients before and after a 3-week oral fish oil supplementation (i.e. EPA + DHA at 1·8 g/d). Plasma glucose fluxes were traced by using [6,6-2H2]glucose infusion. Substrate oxidation was determined by using indirect calorimetry. Each patient was studied in the basal state and over the 6 h following absorption of a 1 g/kg glucose load. Energy expenditure in response to glucose re-increased over the last 2 h of the experiment (P < 0·05), which coincided with an increase in plasma catecholamines, especially epinephrine (P < 0·05), strongly suggesting a sympathoadrenal overactivity. Fish oil supplementation blunted both re-increase in thermogenic response and concomitant increase in plasma epinephrine, but not in plasma norepinephrine, over the last 2 h of the experiment. Fish oil did not alter either whole-body glucose metabolism or substrate oxidation. These data show that in haemodialysis patients, fish oil attenuates adrenal overactivity induced by oral glucose but does not modulate whole-body glucose metabolism and insulin sensitivity.
Type de document :
Article dans une revue
British Journal of Nutrition, Cambridge University Press (CUP), 2008, 99 (05), pp.1117 - 1125. 〈10.1017/S0007114507843534〉
Liste complète des métadonnées
http://hal.univ-brest.fr/hal-01580551
Contributeur : Nicolas Renard <>
Soumis le : vendredi 1 septembre 2017 - 16:41:53
Dernière modification le : jeudi 11 janvier 2018 - 06:17:06

Lien texte intégral

openaccess

Identifiants

Collections

UNIV-BREST | CEMCA-BREST | INC-CNRS

Citation

Jacques Delarue, Marie-Paule Guillodo, Sophie Guillerm, Anthony Elbaz, Yanic Marty, et al.. Fish oil attenuates adrenergic overactivity without altering glucose metabolism during an oral glucose load in haemodialysis patients. British Journal of Nutrition, Cambridge University Press (CUP), 2008, 99 (05), pp.1117 - 1125. 〈10.1017/S0007114507843534〉. 〈hal-01580551〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

56

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD