Cationic Lipids Based on Phosphonate and Phosphoramidate Chemistry: Synthesis and Application to Gene Therapy

Mathieu Mével 1 Jean-Jacques Yaouanc 1 Pascal Laurent 1 Claude Clément 1 Dominique Cartier 1 Paul-Alain Jaffres 1 Tristan Montier 2 Pascal Delépine 2 Tony Le Gall 2 Pierre Lehn 2 Chantal Pichon 3 Patrick Midoux 3 Claude Férec 3
1 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
2 INSERM U613, IFR148
3 CBM - Centre de biophysique moléculaire
Abstract : Cationic lipids having a phosphorus group (phosphonate or phosphoramidate) to link the lipidic part to a cationic head form an efficient family of vectors for DNA delivery. The synthesis of these types of vectors is summarized, including the recent contributions to this field.
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Journal articles
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https://hal.univ-brest.fr/hal-01580434
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Submitted on : Friday, September 1, 2017 - 3:16:37 PM
Last modification on : Thursday, June 20, 2019 - 12:22:09 PM

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Mathieu Mével, Jean-Jacques Yaouanc, Pascal Laurent, Claude Clément, Dominique Cartier, et al.. Cationic Lipids Based on Phosphonate and Phosphoramidate Chemistry: Synthesis and Application to Gene Therapy. Phosphorus, Sulfur, and Silicon and the Related Elements, Taylor & Francis, 2008, 183 (2-3), pp.460 - 468. ⟨10.1080/10426500701761300⟩. ⟨hal-01580434⟩

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