Cationic Lipids Based on Phosphonate and Phosphoramidate Chemistry: Synthesis and Application to Gene Therapy

Abstract : Cationic lipids having a phosphorus group (phosphonate or phosphoramidate) to link the lipidic part to a cationic head form an efficient family of vectors for DNA delivery. The synthesis of these types of vectors is summarized, including the recent contributions to this field.
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https://hal.univ-brest.fr/hal-01580434
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Submitted on : Friday, September 1, 2017 - 3:16:37 PM
Last modification on : Friday, May 24, 2019 - 11:36:07 AM

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Mathieu Mével, Jean-Jacques Yaouanc, Pascal Laurent, Claude Clément, Dominique Cartier, et al.. Cationic Lipids Based on Phosphonate and Phosphoramidate Chemistry: Synthesis and Application to Gene Therapy. Phosphorus, Sulfur, and Silicon and the Related Elements, Taylor & Francis, 2008, 183 (2-3), pp.460 - 468. ⟨10.1080/10426500701761300⟩. ⟨hal-01580434⟩

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