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Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? Results on the Leiden early arthritis clinic and ESPOIR cohorts.

Résumé : A prolonged symptom or disease duration at treatment initiation is associated with unfavourable outcomes in rheumatoid arthritis (RA). It is unknown whether this relation is linear, referring to a common 'the-earlier-the-better principle', or whether a transient time frame in which the disease is more susceptible to treatment exists, referring to a 'window of opportunity'. To elucidate this, we evaluated the shape of the associations of symptom duration with persistence of RA.
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https://hal.univ-brest.fr/hal-01560040
Contributor : Ghislaine Calvez <>
Submitted on : Tuesday, July 11, 2017 - 11:06:01 AM
Last modification on : Thursday, September 3, 2020 - 11:07:49 AM

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B van Nies, R Tsonaka, C Gaujoux-Viala, B Fautrel, a H M van der Helm-van Mil, et al.. Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? Results on the Leiden early arthritis clinic and ESPOIR cohorts.. Annals of the Rheumatic Diseases, BMJ Publishing Group, 2015, 74 (5), pp.806-12. ⟨10.1136/annrheumdis-2014-206047⟩. ⟨hal-01560040⟩

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