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A new classification of HLA-DRB1 alleles based on acid-base properties of the amino acids located at positions 13, 70 and 71: impact on ACPA status or structural progression, and meta-analysis on 1235 patients with rheumatoid from two cohorts (ESPOIR and EAC cohort).

Abstract : To group HLA-DRB1 alleles based on acid-base properties of amino acids at positions 13, 70 and 71 and analyse their association with the presence of anticitrullinated peptide antibodies (ACPA) and structural progression in 2 cohorts of early rheumatoid arthritis (RA).
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https://hal.univ-brest.fr/hal-01560005
Contributor : Ghislaine Calvez <>
Submitted on : Tuesday, July 11, 2017 - 10:37:08 AM
Last modification on : Thursday, July 9, 2020 - 10:18:01 AM

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Adeline Ruyssen-Witrand, Hanna W van Steenbergen, Jurgen van Heemst, Pierre-Antoine Gourraud, Delphine Nigon, et al.. A new classification of HLA-DRB1 alleles based on acid-base properties of the amino acids located at positions 13, 70 and 71: impact on ACPA status or structural progression, and meta-analysis on 1235 patients with rheumatoid from two cohorts (ESPOIR and EAC cohort).. RMD Open : Rheumatic & Musculoskeletal Diseases, EULAR ; BMJ, 2015, 1 (1), pp.e000099. ⟨10.1136/rmdopen-2015-000099⟩. ⟨hal-01560005⟩

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