1GEC - Génie Enzymatique et Cellulaire (Université de Technologie de Compiègne - Centre de Recherche de Royallieu - rue du Docteur Schweitzer- CS 60319 - 60203 COMPIEGNE Cedex - France)
UTC - Université de Technologie de Compiègne (Université de Technologie de Compiègne - Centre de Recherche de Royallieu - rue du Docteur Schweitzer- CS 60319 - 60203 COMPIEGNE Cedex - France)
Abstract : The synthesis of lipophosphoramidyl-β-CD was obtained by an Atherton–Todd (AT) reaction that involved dioleylphosphite and either functionalized permethylated or native β-cyclodextrin. This AT reaction that produced dioleylphosphoramide by making use of the amino group grafted on cyclodextrin, was optimized for these cyclic oligosaccharides. These new amphiphilic compounds were fully characterized, and their self-assembling properties were investigated: the mean size diameter and polydispersity measured by Dynamic Light Scattering (DLS) were affected by the nature of the aqueous media and the temperature of storage. The encapsulation properties of these nanoparticles have been evaluated using carboxyfluorescein and scopolamine derivatives as model of guests.
http://hal.univ-brest.fr/hal-01559137
Contributeur : Nicolas Renard
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Soumis le : lundi 10 juillet 2017 - 14:23:53
Dernière modification le : mercredi 5 septembre 2018 - 14:12:13
