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Journal articles
Synthesis of lipophosphoramidyl-cyclodextrins and their supramolecular properties
Abstract : The synthesis of lipophosphoramidyl-β-CD was obtained by an Atherton–Todd (AT) reaction that involved dioleylphosphite and either functionalized permethylated or native β-cyclodextrin. This AT reaction that produced dioleylphosphoramide by making use of the amino group grafted on cyclodextrin, was optimized for these cyclic oligosaccharides. These new amphiphilic compounds were fully characterized, and their self-assembling properties were investigated: the mean size diameter and polydispersity measured by Dynamic Light Scattering (DLS) were affected by the nature of the aqueous media and the temperature of storage. The encapsulation properties of these nanoparticles have been evaluated using carboxyfluorescein and scopolamine derivatives as model of guests.
https://hal.univ-brest.fr/hal-01559137
Contributor : Nicolas Renard <>
Submitted on : Monday, July 10, 2017 - 2:23:53 PM
Last modification on : Wednesday, April 14, 2021 - 10:56:02 AM
Contributor : Nicolas Renard <>
Submitted on : Monday, July 10, 2017 - 2:23:53 PM
Last modification on : Wednesday, April 14, 2021 - 10:56:02 AM