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Journal articles
Evaluation of serum interleukin-6 level as a surrogate marker of synovial inflammation and as a factor of structural progression in early rheumatoid arthritis: results from a French national multicenter cohort.
Athan Baillet
Laure Gossec
1
Simon Paternotte
2
Adrien Etcheto
2
Bernard Combe
3, 4
Olivier Meyer
5, 6
Xavier Mariette
7, 8
Jacques-Eric Gottenberg
9
Maxime Dougados
2
Alain Saraux
10, 11, 12
Bernard Combe 3, 4
Author
Olivier Meyer 5, 6
Author
Xavier Mariette 7, 8
Author
Jacques-Eric Gottenberg 9
Author
Maxime Dougados 2
Author
Alain Saraux 10, 11, 12
Mail :
Other
1
Service de Rhumatologie [CHU Pitié-Salpêtrière] (France)
- APHP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Pitié-Salpêtrière [APHP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
2
Service de rhumatologie [CHU Cochin] (27 rue du Faubourg Saint-Jacques 75014 Paris - France)
- CHU Cochin [AP-HP] (27 Rue du Faubourg Saint-Jacques 75014 Paris - France)
- APHP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
3
Département de Rhumatologie[Montpellier] (371, avenue du Doyen Gaston Giraud 34295 Montpellier cedex 5 - France)
- CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier] (191 avenue du doyen Gaston Giraud 34295 Montpellier cedex 5 - France)
- Hôpital Lapeyronie (France)
4
IGMM - Institut de Génétique Moléculaire de Montpellier (1919 Route de Mende - 34293 Montpellier Cedex 5 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5535 (France)
- UM - Université de Montpellier (163 rue Auguste Broussonnet - 34090 Montpellier - France)
5
UPD7 - Université Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
6
Hôpital Bichat, AP-HP (France)
7
Service de rhumatologie (Le Kremlin-Bicêtre - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- APHP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Hôpital Bicêtre (France)
8
Régulation de la réponse immune, infection VIH-1 et autoimmunité (63, rue Gabriel Péri, 94276 Le Kremlin-Bicêtre - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1012 (101, rue de Tolbiac, 75013 Paris - France)
9
Immuno-Rhumatologie Moléculaire (1 Place de l'Hôpital 67000 Strasbourg - France)
- UNISTRA - Université de Strasbourg : UMRS1109 (4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1109 (101, rue de Tolbiac, 75013 Paris - France)
10
CIC 1412 - BREST - Centre d'Investigation Clinique INSERM 1412 (Hôpital de la Cavale Blanche
boulevard Tanguy Prigent
29609 BREST CEDEX - France)
11
LBAI - Lymphocyte B et Auto-immunité (5 Foch - CHU Morvan - BP 824 - 29609 Brest - France - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1227 (101, rue de Tolbiac, 75013 Paris - France)
- IBSAM - Institut Brestois Santé Agro Matière (Université de Brest- UBO
29238 Brest - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
12
CHU - BREST - Rhumato - CHRU Brest - Service de Rhumatologie (Hôpital de la Cavale Blanche, Boulevard Tanguy Prigent, 29200 Brest - France)
Abstract : Interleukin-6 (IL-6) is a key cytokine in rheumatoid arthritis pathogenesis. We aimed to analyze the association between IL-6 serum levels and joint inflammation at baseline and the correlation of time-integrated IL-6 values with structural damage during the first 36 months of early arthritis.
Abstract : IL-6 was assessed by 2 different methods in 813 patients of the French early arthritis cohort ESPOIR (Etude et Suivi des Polyarthrites Indifférenciées Récentes) over 36 months. IL-6 and C-reactive protein (CRP) changes were correlated to radiographic progression assessed by the total Sharp/van der Heijde score (SHS). Synovium inflammation was assessed in a subgroup of 126 patients by ultrasonography (US). The relationship between SHS change and IL-6 or CRP levels at baseline was investigated by a univariate regression and a multivariable analysis. A longitudinal model nested by visit and patient was conducted to assess the role of IL-6 on SHS at each visit.
Abstract : At baseline, IL-6 was more strongly correlated with the swollen joint count than CRP level. In the univariate analysis, the time-integrated value of IL-6 was more strongly correlated with the swollen joint count and the variation of SHS than time-integrated CRP level. Baseline IL-6 was not independently associated with SHS change. Longitudinal models nested by patient showed that IL-6 levels were associated with structural damage independently from the Disease Activity Score in 28 joints, smoking status, rheumatoid factor, and anti-citrullinated protein peptide antibody serology, treatments, and CRP levels.
Abstract : IL-6 level was a marker of US synovitis at baseline. Repeated measurements of IL-6 are associated with structural damage.
Complete list of metadatas
https://hal.univ-brest.fr/hal-01559126
Contributor : Ghislaine Calvez <>
Submitted on : Monday, July 10, 2017 - 2:14:57 PM
Last modification on : Friday, March 27, 2020 - 3:42:47 AM
Contributor : Ghislaine Calvez <>
Submitted on : Monday, July 10, 2017 - 2:14:57 PM
Last modification on : Friday, March 27, 2020 - 3:42:47 AM
Identifiers
- HAL Id : hal-01559126, version 1
- PUBMED : 25384758
Collections
UNIV-BREST | CNRS | UNIV-PARIS7 | IMMUNO | USPC | UNIV-PARIS-SACLAY | BS | UNIV-MONTPELLIER | SITE-ALSACE | IBSAM
Citation
Athan Baillet, Laure Gossec, Simon Paternotte, Adrien Etcheto, Bernard Combe, et al.. Evaluation of serum interleukin-6 level as a surrogate marker of synovial inflammation and as a factor of structural progression in early rheumatoid arthritis: results from a French national multicenter cohort.. Arthritis Care & Research = Arthritis Care and Research, Wiley-Blackwell, 2015, 67 (7), pp.905-12. ⟨hal-01559126⟩
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