Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. - Université de Bretagne Occidentale Access content directly
Journal Articles Nature Genetics Year : 2013

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

He Li
  • Function : Author
Indra Adrianto
  • Function : Author
John A Ice
  • Function : Author
Astrid Rasmussen
  • Function : Author
Kiely M Grundahl
  • Function : Author
Mikhail G Dozmorov
  • Function : Author
Per Eriksson
  • Function : Author
Lasse G Gøransson
  • Function : Author
Erna Harboe
  • Function : Author
Joel M Guthridge
  • Function : Author
Kenneth M Kaufman
  • Function : Author
Marika Kvarnström
  • Function : Author
Helmi Jazebi
  • Function : Author
Deborah S Cunninghame Graham
  • Function : Author
Martha E Grandits
  • Function : Author
Abu N M Nazmul-Hossain
  • Function : Author
Ketan Patel
  • Function : Author
Adam J Adler
  • Function : Author
Jacen S Maier-Moore
  • Function : Author
a Darise Farris
  • Function : Author
Kimberly S Hefner
  • Function : Author
Glen D Houston
  • Function : Author
Lida Radfar
  • Function : Author
Michael D Rohrer
  • Function : Author
Jonathan D Wren
  • Function : Author
Roald Omdal
  • Function : Author
Marie Wahren-Herlenius
  • Function : Author
Gabor G Illei
  • Function : Author
Torsten Witte
  • Function : Author
Maureen Rischmueller
  • Function : Author
Wan-Fai Ng
  • Function : Author
Xavier Mariette
Juan-Manuel Anaya
Nelson L Rhodus
  • Function : Author
Barbara M Segal
  • Function : Author
R Hal Scofield
  • Function : Author
Kathy L Sivils
  • Function : Author
He Lessard
  • Function : Author
Deborah S Cunninghame Graham
  • Function : Author

Abstract

Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjögren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BLK (Pmeta = 4.97 × 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 × 10(-8)) and TNIP1 (Pmeta = 3.30 × 10(-8)). We also observed suggestive associations (Pmeta < 5 × 10(-5)) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome.

Dates and versions

hal-01558145 , version 1 (07-07-2017)

Identifiers

Cite

Christopher J Lessard, He Li, Indra Adrianto, John A Ice, Astrid Rasmussen, et al.. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.. Nature Genetics, 2013, 45 (11), pp.1284-92. ⟨10.1038/ng.2792⟩. ⟨hal-01558145⟩
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