Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

Christopher J Lessard; He Li; Indra Adrianto; John A Ice; Astrid Rasmussen; Kiely M Grundahl; Jennifer A Kelly; Mikhail G Dozmorov; Corinne Miceli-Richard; Simon Bowman; Sue Lester; Per Eriksson; Maija-Leena Eloranta; Johan G Brun; Lasse G Gøransson; Erna Harboe; Joel M Guthridge; Kenneth M Kaufman; Marika Kvarnström; Helmi Jazebi; Deborah S Cunninghame Graham; Martha E Grandits; Abu N M Nazmul-Hossain; Ketan Patel; Adam J Adler; Jacen S Maier-Moore; a Darise Farris; Michael T Brennan; James James; Judith A James; Rajaram Gopalakrishnan; Kimberly S Hefner; Glen D Houston; Andrew J W Huang; Pamela J Hughes; David M Lewis; Lida Radfar; Michael D Rohrer; Donald U Stone; Jonathan D Wren; Timothy J Vyse; Patrick M Gaffney; Roald Omdal; Marie Wahren-Herlenius; Gabor G Illei; Torsten Witte; Roland Jonsson; Maureen Rischmueller; Lars Rönnblom; Gunnel Nordmark; Wan-Fai Ng; Xavier Mariette; Juan-Manuel Anaya; Nelson L Rhodus; Barbara M Segal; R Hal Scofield; Courtney G Montgomery; John B Harley; Kathy L Sivils; He Lessard; Deborah S Cunninghame Graham; Alain Saraux

doi:10.1038/ng.2792

Journal Articles Nature Genetics Year : 2013

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

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Christopher J Lessard

Function : Author

University of Oklahoma Health Sciences Center

He Li

Function : Author

Indra Adrianto

Function : Author

John A Ice

Function : Author

Astrid Rasmussen

Function : Author

Kiely M Grundahl

Function : Author

Jennifer A Kelly

Function : Author

Macquarie University

Mikhail G Dozmorov

Function : Author

Corinne Miceli-Richard

Function : Author

Service de rhumatologie

Simon Bowman

Function : Author

New Queen Elizabeth Hospital

Sue Lester

Function : Author

Marine Science Institute

Per Eriksson

Function : Author

Maija-Leena Eloranta

Function : Author

Department of Medical Sciences

Johan G Brun

Function : Author

Université de Genève = University of Geneva

Lasse G Gøransson

Function : Author

Erna Harboe

Function : Author

Joel M Guthridge

Function : Author

Kenneth M Kaufman

Function : Author

Marika Kvarnström

Function : Author

Helmi Jazebi

Function : Author

Deborah S Cunninghame Graham

Function : Author

Martha E Grandits

Function : Author

Abu N M Nazmul-Hossain

Function : Author

Ketan Patel

Function : Author

Adam J Adler

Function : Author

Jacen S Maier-Moore

Function : Author

a Darise Farris

Function : Author

Michael T Brennan

Function : Author

Institute of Sound and Vibration Research

James James

Function : Author

Centre for Cybersecurity and Cybercrime Investigation [Dublin]

Judith A James

Function : Author

Centre for Cybersecurity and Cybercrime Investigation [Dublin]

Rajaram Gopalakrishnan

Function : Author

Computing and Mathematical Sciences [Pasadena]]

Kimberly S Hefner

Function : Author

Glen D Houston

Function : Author

Andrew J W Huang

Function : Author

Zhejiang University

Pamela J Hughes

Function : Author

University of Southampton

David M Lewis

Function : Author

Laboratoire de l'intégration, du matériau au système

Lida Radfar

Function : Author

Michael D Rohrer

Function : Author

Donald U Stone

Function : Author

Climate Systems Analysis Group [Cape Town]

Jonathan D Wren

Function : Author

Timothy J Vyse

Function : Author

Faculty of Medicine

Patrick M Gaffney

Function : Author

Department of Pathology

Department of Pathology, Immunology and Microbiology

Roald Omdal

Function : Author

Marie Wahren-Herlenius

Function : Author

Gabor G Illei

Function : Author

Torsten Witte

Function : Author

Roland Jonsson

Function : Author

Swedish Defence Research Agency [Stockholm]

Maureen Rischmueller

Function : Author

Lars Rönnblom

Function : Author

Department of Medical Sciences

Gunnel Nordmark

Function : Author

Department of Medical Sciences

Wan-Fai Ng

Function : Author

Xavier Mariette

Function : Author
PersonId : 756829
ORCID : 0000-0002-4244-5417
IdRef : 113094116

Service de rhumatologie

Juan-Manuel Anaya

Function : Author
PersonId : 767596
ORCID : 0000-0002-6444-1249
IdRef : 234685212

Nelson L Rhodus

Function : Author

Barbara M Segal

Function : Author

R Hal Scofield

Function : Author

Courtney G Montgomery

Function : Author

Department of Public Health & Policy

John B Harley

Function : Author

University of Alberta

Kathy L Sivils

Function : Author

He Lessard

Function : Author

Deborah S Cunninghame Graham

Function : Author

Alain Saraux

Function : Other
PersonId : 929631

Centre d'Investigation Clinique

Lymphocytes B, Autoimmunité et Immunothérapies

CHRU Brest - Service de Rhumatologie

Abstract

Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjögren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BLK (Pmeta = 4.97 × 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 × 10(-8)) and TNIP1 (Pmeta = 3.30 × 10(-8)). We also observed suggestive associations (Pmeta < 5 × 10(-5)) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome.

Domains

Life Sciences [q-bio] Human health and pathology Rhumatology and musculoskeletal system

Ghislaine Calvez : Connect in order to contact the contributor

https://hal.univ-brest.fr/hal-01558145

Submitted on : Friday, July 7, 2017-11:00:28 AM

Last modification on : Monday, June 5, 2023-4:52:11 PM

Dates and versions

hal-01558145 , version 1 (07-07-2017)

Identifiers

HAL Id : hal-01558145 , version 1
DOI : 10.1038/ng.2792
PUBMED : 24097067
PUBMEDCENTRAL : PMC3867192

Cite

Christopher J Lessard, He Li, Indra Adrianto, John A Ice, Astrid Rasmussen, et al.. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.. Nature Genetics, 2013, 45 (11), pp.1284-92. ⟨10.1038/ng.2792⟩. ⟨hal-01558145⟩

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Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

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