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Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

Christopher J Lessard 1 He Li Indra Adrianto John A Ice Astrid Rasmussen Kiely M Grundahl Jennifer A Kelly 2 Mikhail G Dozmorov Corinne Miceli-Richard 3 Simon Bowman 4 Sue Lester 5 Per Eriksson Maija-Leena Eloranta 6 Johan G Brun 7 Lasse G Gøransson Erna Harboe Joel M Guthridge Kenneth M Kaufman Marika Kvarnström Helmi Jazebi Deborah S Cunninghame Graham Martha E Grandits Abu N M Nazmul-Hossain Ketan Patel Adam J Adler Jacen S Maier-Moore a Darise Farris Michael T Brennan 8 James James 9 Judith A James 9 Rajaram Gopalakrishnan 10 Kimberly S Hefner Glen D Houston Andrew J W Huang 11 Pamela J Hughes 12 David M Lewis 13 Lida Radfar Michael D Rohrer Donald U Stone 14 Jonathan D Wren Timothy J Vyse 15 Patrick M Gaffney 16, 17 Roald Omdal Marie Wahren-Herlenius Gabor G Illei Torsten Witte Roland Jonsson 18 Maureen Rischmueller Lars Rönnblom 6 Gunnel Nordmark 6 Wan-Fai Ng Xavier Mariette 3 Juan-Manuel Anaya Nelson L Rhodus Barbara M Segal R Hal Scofield Courtney G Montgomery 19 John B Harley 20 Kathy L Sivils He Lessard Deborah S Cunninghame Graham Alain Saraux 21, 22, 23
1 OUHSC - University of Oklahoma Health Sciences Center
2 Macquarie University
3 Service de rhumatologie
4 NQEH - BIRMINGHAM - New Queen Elizabeth Hospital
5 Marine Science Institute
6 Department of Medical Sciences
7 UNIGE - Université de Genève
8 Institute of Sound and Vibration Research
University of Southampton
9 CCI - Centre for Cybersecurity and Cybercrime Investigation [Dublin]
10 Computing and Mathematical Sciences [Pasadena]]
11 Zhejiang University
12 University of Southampton
13 IMS - Laboratoire de l'intégration, du matériau au système
14 CSAG - Climate Systems Analysis Group [Cape Town]
University of Cape Town
15 Faculty of Medicine
16 Department of Pathology
17 Department of Pathology, Immunology and Microbiology
18 FOI - Swedish Defence Research Agency [Stockholm]
19 Department of Public Health & Policy
20 University of Alberta
21 CIC 1412 - BREST - Centre d'Investigation Clinique INSERM 1412
22 LBAI - Lymphocyte B et Auto-immunité
23 CHU - BREST - Rhumato - CHRU Brest - Service de Rhumatologie
Abstract : Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjögren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BLK (Pmeta = 4.97 × 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 × 10(-8)) and TNIP1 (Pmeta = 3.30 × 10(-8)). We also observed suggestive associations (Pmeta < 5 × 10(-5)) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome.
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Journal articles
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https://hal.univ-brest.fr/hal-01558145
Contributor : Ghislaine Calvez <>
Submitted on : Friday, July 7, 2017 - 11:00:28 AM
Last modification on : Tuesday, June 30, 2020 - 9:48:17 AM

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  • HAL Id : hal-01558145, version 1
  • PUBMED : 24097067

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UNIV-BREST | CNRS | IMS-BORDEAUX-FUSION | IMS-BORDEAUX | IMMUNO | IBSAM

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Christopher J Lessard, He Li, Indra Adrianto, John A Ice, Astrid Rasmussen, et al.. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.. Nature Genetics, Nature Publishing Group, 2013, 45 (11), pp.1284-92. ⟨hal-01558145⟩

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