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Impact of co-morbidities on measuring indirect utility by the Medical Outcomes Study Short Form 6D in lower-limb osteoarthritis

Résumé : Co-morbidities can influence generic measurement of health indirect utility. We investigated their impact to assess indirect utility with the Medical Outcomes Study Short Form 6D (SF-6D) in patients with osteoarthritis (OA). In patients with hip and knee OA from the Knee and Hip Osteo-Arthritis Long-term Assessment (KHOALA) study, co-morbidities were assessed by the Functional Co-morbidity Index. Multivariate linear regressions were used to determine predictors of utility score.For the 878 patients included, the mean (standard deviation (SD)) utility score for 808 patients was 0.66 (11; range 0.32-1.00) and mean number of co-morbidities 2.05 (1.58). Number of co-morbidities (beta = -0.30; p = 0.002), psychiatric disease (beta = -0.043; p < 0.0001) and degenerative disc disease (beta = -0.014; p = 0.018) were predictors of low utility score. The WOMAC functional score had a higher significant effect (beta = -0.003; p < 0.0001) and explained a higher percentage of the model variance.
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https://hal.univ-brest.fr/hal-01557770
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Submitted on : Thursday, July 6, 2017 - 3:33:48 PM
Last modification on : Friday, January 28, 2022 - 1:44:01 PM

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Kossar Hosseini, Cécile Gaujoux-Viala, Joel Coste, Jacques Pouchot, Bruno Fautrel, et al.. Impact of co-morbidities on measuring indirect utility by the Medical Outcomes Study Short Form 6D in lower-limb osteoarthritis. Best Practice and Research: Clinical Rheumatology, Elsevier, 2012, 26 (5), pp.627-35. ⟨10.1016/j.berh.2012.08.007⟩. ⟨hal-01557770⟩

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