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Glyco-phospho-glycero-ether lipid as modulator of SK3 ion channel and SK3-dependent cancer cell migration

C. Sevrain 1 Wilfried Berthe 1 Hélène Couthon 1 J. P. Haelters 1 M. Bouchet 2 A. Chantôme 2 M. Potier-Cartereau 2 C. Vandier 2 Paul-Alain Jaffres 1
1 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
2 Inserm UMR1069
N2C - Nutrition, croissance et cancer (U 1069)
Abstract : In this short review paper, we report our efforts to design new inhibitors of SK3 ion channel that are involved in cancer cell migration and metastases formation. The originality of the new SK3 inhibitors comes from their amphiphilic nature and contrast form others inhibitors that are peptides or heterocyclic compounds. We found that ether lipids and ether phospho-glyco-lipids are indeed efficient to modulate SK3 ion channel that consequently reduced cancer cell migration (in vitro assays) and abolished the formation of bone metastases in a murine model of breast cancer.
Keywords : phosphate potassium ion channel Phospholipids glycol-lipids ether lipids SK3 ion channel
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https://hal.univ-brest.fr/hal-01539329
Contributor : Nicolas Renard <>
Submitted on : Wednesday, June 14, 2017 - 4:26:52 PM
Last modification on : Thursday, November 29, 2018 - 4:09:19 PM

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C. Sevrain, Wilfried Berthe, Hélène Couthon, J. P. Haelters, M. Bouchet, et al.. Glyco-phospho-glycero-ether lipid as modulator of SK3 ion channel and SK3-dependent cancer cell migration. Phosphorus, Sulfur, and Silicon and the Related Elements, Taylor & Francis, 2016, 191 (11-12), pp.1623 - 1624. ⟨10.1080/10426507.2016.1217221⟩. ⟨hal-01539329⟩

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