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A tandem mass spectrometry-based method to assess the architectural purity of synthetic polymers: a case of a cyclic polylactide obtained by click chemistry

Abstract : A tandem mass spectrometry-based method is developed to determine the degree of purity achieved in the cyclization of a linear poly(L-lactide) prepared by copper-catalyzed alkyne-azide cycloaddition. When proton nuclear magnetic resonance, size-exclusion chromatography, and single-stage mass spectrometry are unable to demonstrate the presence of a residual linear polymer, the proposed ESI-tandem mass spectrometry methodology allows detection of starting material traces (<5%) based on radically different collision-induced dissociation (CID) behaviours. The technique is believed to be readily adaptable to numerous isomeric pairs of macromolecules presenting different CID characteristics.
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https://hal.univ-brest.fr/hal-01538525
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Submitted on : Tuesday, June 13, 2017 - 4:30:20 PM
Last modification on : Friday, September 6, 2019 - 3:28:02 PM

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Thomas Josse, Julien de Winter, Philippe Dubois, Olivier Coulembier, Pascal Gerbaux, et al.. A tandem mass spectrometry-based method to assess the architectural purity of synthetic polymers: a case of a cyclic polylactide obtained by click chemistry. Polymer Chemistry, Royal Society of Chemistry - RSC, 2014, 6 (1), pp.64 - 69. ⟨10.1039/C4PY01087F⟩. ⟨hal-01538525⟩

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