A tandem mass spectrometry-based method to assess the architectural purity of synthetic polymers: a case of a cyclic polylactide obtained by click chemistry - Université de Bretagne Occidentale Access content directly
Journal Articles Polymer Chemistry Year : 2014

A tandem mass spectrometry-based method to assess the architectural purity of synthetic polymers: a case of a cyclic polylactide obtained by click chemistry

Abstract

A tandem mass spectrometry-based method is developed to determine the degree of purity achieved in the cyclization of a linear poly(L-lactide) prepared by copper-catalyzed alkyne-azide cycloaddition. When proton nuclear magnetic resonance, size-exclusion chromatography, and single-stage mass spectrometry are unable to demonstrate the presence of a residual linear polymer, the proposed ESI-tandem mass spectrometry methodology allows detection of starting material traces (<5%) based on radically different collision-induced dissociation (CID) behaviours. The technique is believed to be readily adaptable to numerous isomeric pairs of macromolecules presenting different CID characteristics.
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Dates and versions

hal-01538525 , version 1 (13-06-2017)

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Thomas Josse, Julien de Winter, Philippe Dubois, Olivier Coulembier, Pascal Gerbaux, et al.. A tandem mass spectrometry-based method to assess the architectural purity of synthetic polymers: a case of a cyclic polylactide obtained by click chemistry. Polymer Chemistry, 2014, 6 (1), pp.64 - 69. ⟨10.1039/C4PY01087F⟩. ⟨hal-01538525⟩
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