HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

Abstract : The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron–oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T2 MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 (t1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging.
Document type :
Journal articles
Complete list of metadata

https://hal.univ-brest.fr/hal-01537630
Contributor : Nicolas Renard Connect in order to contact the contributor
Submitted on : Monday, June 12, 2017 - 5:04:12 PM
Last modification on : Monday, October 11, 2021 - 2:22:08 PM

Links full text

Identifiers

Collections

Citation

Benjamin P. Burke, Neazar Baghdadi, Alicja E. Kownacka, Shubhanchi Nigam, Goncalo S. Clemente, et al.. Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions. Nanoscale, Royal Society of Chemistry, 2015, 7 (36), pp.14889 - 14896. ⟨10.1039/C5NR02753E⟩. ⟨hal-01537630⟩

Share

Metrics

Record views

47