Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

Benjamin P. Burke 1, 2 Neazar Baghdadi 1 Alicja E. Kownacka 1 Shubhanchi Nigam 2, 1 Goncalo S. Clemente 3 Mustafa M. Al-Yassiry 1 Juozas Domarkas 2, 1 Mark Lorch 1 Martin Pickles 4 Peter Gibbs 4 Raphaël Tripier 5 Christopher Cawthorne 2, 3 Stephen J. Archibald 2, 1
1 Department of Chemistry, Hull University
2 Positron Emission Tomography Research Centre and Department of Chemistry
3 School of Biological, Biomedical and Environmental Sciences
4 Centre for Magnetic Resonance Investigations
5 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
Abstract : The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron–oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T2 MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 (t1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging.
Type de document :
Article dans une revue
Nanoscale, Royal Society of Chemistry, 2015, 7 (36), pp.14889 - 14896. 〈http://pubs.rsc.org/en/content/articlehtml/2015/NR/C5NR02753E〉. 〈10.1039/C5NR02753E〉
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http://hal.univ-brest.fr/hal-01537630
Contributeur : Nicolas Renard <>
Soumis le : lundi 12 juin 2017 - 17:04:12
Dernière modification le : jeudi 11 janvier 2018 - 06:17:06

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Benjamin P. Burke, Neazar Baghdadi, Alicja E. Kownacka, Shubhanchi Nigam, Goncalo S. Clemente, et al.. Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions. Nanoscale, Royal Society of Chemistry, 2015, 7 (36), pp.14889 - 14896. 〈http://pubs.rsc.org/en/content/articlehtml/2015/NR/C5NR02753E〉. 〈10.1039/C5NR02753E〉. 〈hal-01537630〉

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