HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Intracellular Transport Studies of Picolinate Macrocyclic Copper and Lanthanide Complexes

Abstract : In vivo molecular imaging involves different techniques to image cellular biochemical processes. Metal complexes can be used as cell-permeable medical imaging agents. In this work we studied the cytotoxicity and the cellular incorporation kinetics of two recently synthesized picolinate macrocyclic complexes, [Eu(do2pa)]+ and [Cu(te1pa)]+. Both complexes are able to enter inside the cells. The intracellular concentration (Ci) of [Eu(do2pa)]+ is ∼5 times the extracellular concentration (Ce). In the case of [Cu(te1pa)]+, the ratio Ci/Ce is approximately 1.4. Furthermore, the results suggest that these complexes are not substrates of P-gp, an efflux transport protein involved in the mechanisms of multidrug resistance in cancer cells and in the low permeability of blood-brain barrier. The results obtained here, added to their physicochemical properties, let us propose that the complexes studied could be suitable platforms for the synthesis of cell-permeable MRI contrast agents or PET tracers.
Document type :
Journal articles
Complete list of metadata

https://hal.univ-brest.fr/hal-01518187
Contributor : Maryline Beyler Connect in order to contact the contributor
Submitted on : Thursday, May 4, 2017 - 1:20:07 PM
Last modification on : Tuesday, December 14, 2021 - 8:12:02 AM

Identifiers

Citation

Diego Santo Domingo Porqueras, Maryline Beyler, Raphaël Tripier, Milena Salerno. Intracellular Transport Studies of Picolinate Macrocyclic Copper and Lanthanide Complexes. ChemistrySelect, Wiley, 2016, 1 (15), pp.4423 - 4429. ⟨10.1002/slct.201600990⟩. ⟨hal-01518187⟩

Share

Metrics

Record views

138