Cationic Two-Photon Lanthanide Bioprobes Able to Accumulate in Live Cells

Anh Thy Bui 1 Maryline Beyler 2 Yuan-Yuan Liao 1 Alexei Grichine 3 Alain Duperray 3 Jean-Christophe Mulatier 1 Boris Le Guennic 4 Chantal Andraud 1 Olivier Maury 1 Raphaël Tripier 2
1 LC - Laboratoire de Chimie - UMR5182
2 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
3 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
4 ISCR - Institut des Sciences Chimiques de Rennes
Abstract : An original cationic water-soluble cyclen-based Eu(III) complex [EuL1]+ featuring a chromophore-functionalized antenna to increase the two-photon (2P) absorption properties was synthesized. The photophysical properties were thoroughly studied in various solvents and rationalized with the help of theoretical calculations. The complex exhibits an optimized 2P absorption cross section. Finally, 2P microscopy imaging experiments on living T24 human cancer cells highlighted the spontaneous internalization and the biological stability of this 2P bioprobe in vitro. Macrocyclic-based antennas open new perspectives for future optimization of the photophysical properties and allows envisaging the design of Eu, Tb, Yb, and Sm bioprobes. This result also opens the way for the design of functional two-photon Ln complexes able to monitor intracellular physicochemical parameters.
Keywords : europium complexes, luminescence, microscopy, terbium, excitation, triazacyclononane, emission, ligands, number
Type de document :
Article dans une revue
Inorganic Chemistry, American Chemical Society, 2016, 55 (14), pp.7020 - 7025. 〈10.1021/acs.inorgchem.6b00891〉
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http://hal.univ-brest.fr/hal-01517789
Contributeur : Maryline Beyler <>
Soumis le : mercredi 3 mai 2017 - 16:14:11
Dernière modification le : vendredi 25 mai 2018 - 01:26:15

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Citation

Anh Thy Bui, Maryline Beyler, Yuan-Yuan Liao, Alexei Grichine, Alain Duperray, et al.. Cationic Two-Photon Lanthanide Bioprobes Able to Accumulate in Live Cells. Inorganic Chemistry, American Chemical Society, 2016, 55 (14), pp.7020 - 7025. 〈10.1021/acs.inorgchem.6b00891〉. 〈hal-01517789〉

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