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H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications

Luís M. P. Lima 1 Maryline Beyler 2 Fatima Oukhatar 2 Patricia Le Saec 3 Alain Faivre-Chauvet 3 Carlos Platas-Iglesias 4 Rita Delgado 1 Raphaël Tripier 2
1 ITQB - Instituto de Tecnologia Química e Biológica António Xavier
2 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
3 CRCNA - Centre de Recherche en Cancérologie Nantes-Angers
4 Departamento de Química Fundamental
Abstract : The complexation properties of H2Me-do2pa towards natBi3+ reveal a rather fast formation of the [Bi(Me-do2pa)]+ complex, which is endowed with a very high thermodynamic stability (log KBiL = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of H2Me-do2pa with 213Bi was performed and the resulting complex was stable in vitro, sustaining its use as an attractive alternative to H4dota taken here as a reference.
Keywords : coordination chemistry radiochemistry
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Journal articles
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https://hal.univ-brest.fr/hal-01517757
Contributor : Maryline Beyler <>
Submitted on : Wednesday, May 3, 2017 - 3:53:25 PM
Last modification on : Friday, June 19, 2020 - 3:08:50 AM

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Luís M. P. Lima, Maryline Beyler, Fatima Oukhatar, Patricia Le Saec, Alain Faivre-Chauvet, et al.. H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications. Chemical Communications, Royal Society of Chemistry, 2014, 50 (82), pp.12371 - 12374. ⟨10.1039/C4CC05529B⟩. ⟨hal-01517757⟩

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