H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications - Université de Bretagne Occidentale Access content directly
Journal Articles Chemical Communications Year : 2014

H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications

Abstract

The complexation properties of H2Me-do2pa towards natBi3+ reveal a rather fast formation of the [Bi(Me-do2pa)]+ complex, which is endowed with a very high thermodynamic stability (log KBiL = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of H2Me-do2pa with 213Bi was performed and the resulting complex was stable in vitro, sustaining its use as an attractive alternative to H4dota taken here as a reference.
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hal-01517757 , version 1 (03-05-2017)

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Luís M. P. Lima, Maryline Beyler, Fatima Oukhatar, Patricia Le Saec, Alain Faivre-Chauvet, et al.. H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications. Chemical Communications, 2014, 50 (82), pp.12371 - 12374. ⟨10.1039/C4CC05529B⟩. ⟨hal-01517757⟩
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