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Journal articles
H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications
Abstract : The complexation properties of H2Me-do2pa towards natBi3+ reveal a rather fast formation of the [Bi(Me-do2pa)]+ complex, which is endowed with a very high thermodynamic stability (log KBiL = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of H2Me-do2pa with 213Bi was performed and the resulting complex was stable in vitro, sustaining its use as an attractive alternative to H4dota taken here as a reference.
Keywords :
coordination chemistry
radiochemistry
https://hal.univ-brest.fr/hal-01517757
Contributor : Maryline Beyler Connect in order to contact the contributor
Submitted on : Wednesday, May 3, 2017 - 3:53:25 PM
Last modification on : Monday, October 11, 2021 - 2:22:08 PM
Contributor : Maryline Beyler Connect in order to contact the contributor
Submitted on : Wednesday, May 3, 2017 - 3:53:25 PM
Last modification on : Monday, October 11, 2021 - 2:22:08 PM
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