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Journal articles
H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications
Luís M. P. Lima
1
Maryline Beyler
2
Fatima Oukhatar
2
Patricia Le Saec
3
Alain Faivre-Chauvet
3
Carlos Platas-Iglesias
4
Rita Delgado
1
Raphaël Tripier
2
Luís M. P. Lima 1
Author
Maryline Beyler 2
Mail :
Author IdHAL : marylinebeyler
Fatima Oukhatar 2
Author
Patricia Le Saec 3
Author
Alain Faivre-Chauvet 3
Author
Carlos Platas-Iglesias 4
Author
Rita Delgado 1
Author
Raphaël Tripier 2
Mail :
Author IdHAL : raphael-tripier ORCID : https://orcid.org/0000-0001-9364-788X
1
ITQB - Instituto de Tecnologia Química e Biológica António Xavier (Avenida da República
Estação Agronómica Nacional
2780-157 Oeiras - Portugal)
- NOVA - Universidade Nova de Lisboa = NOVA University of Lisboa (Campus de Campolide 1099-085 Lisboa - Portugal)
2
CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique (6 Av Victor Le Gorgeu - BP 809 29285 BREST CEDEX - France)
- IBSAM - Institut Brestois Santé Agro Matière (Université de Brest- UBO
29238 Brest - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
- CNRS - Centre National de la Recherche Scientifique : UMR6521 (France)
- INC - Institut de Chimie du CNRS (3 Rue Michel-Ange 75 016 Paris - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
3
CRCNA - Centre de Recherche en Cancérologie Nantes-Angers (France)
- CHU Angers - Centre Hospitalier Universitaire d'Angers (4 rue Larrey - 49933 Angers cedex 9 - France)
- Hôtel-Dieu de Nantes (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France)
- Hôpital Laennec (France)
- CNRS - Centre National de la Recherche Scientifique (France)
- Faculté de Médecine d'Angers (Rue Haute de Reculée 49045 Angers - France)
- CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
4
Departamento de Química Fundamental (Universidade da Coruña, Campus da Zapateira, Rúa da Fraga 10, 15008 A Coruña - Spain)
- Universidade da Coruña (Rúa da Maestranza 9, 15001 A Coruña - Spain)
Abstract : The complexation properties of H2Me-do2pa towards natBi3+ reveal a rather fast formation of the [Bi(Me-do2pa)]+ complex, which is endowed with a very high thermodynamic stability (log KBiL = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of H2Me-do2pa with 213Bi was performed and the resulting complex was stable in vitro, sustaining its use as an attractive alternative to H4dota taken here as a reference.
Keywords :
coordination chemistry
radiochemistry
Document type :
Journal articles
Complete list of metadatas
https://hal.univ-brest.fr/hal-01517757
Contributor : Maryline Beyler <>
Submitted on : Wednesday, May 3, 2017 - 3:53:25 PM
Last modification on : Friday, June 19, 2020 - 3:08:50 AM
Contributor : Maryline Beyler <>
Submitted on : Wednesday, May 3, 2017 - 3:53:25 PM
Last modification on : Friday, June 19, 2020 - 3:08:50 AM
Identifiers
- HAL Id : hal-01517757, version 1
- DOI : 10.1039/C4CC05529B
Collections
UNIV-BREST | CNRS | CEMCA-BREST | INC-CNRS | UNAM | IBSAM
Citation
Luís M. P. Lima, Maryline Beyler, Fatima Oukhatar, Patricia Le Saec, Alain Faivre-Chauvet, et al.. H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications. Chemical Communications, Royal Society of Chemistry, 2014, 50 (82), pp.12371 - 12374. ⟨10.1039/C4CC05529B⟩. ⟨hal-01517757⟩
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