H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications

Abstract : The complexation properties of H2Me-do2pa towards natBi3+ reveal a rather fast formation of the [Bi(Me-do2pa)]+ complex, which is endowed with a very high thermodynamic stability (log KBiL = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of H2Me-do2pa with 213Bi was performed and the resulting complex was stable in vitro, sustaining its use as an attractive alternative to H4dota taken here as a reference.
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Chemical Communications, Royal Society of Chemistry, 2014, 50 (82), pp.12371 - 12374. 〈10.1039/C4CC05529B〉
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http://hal.univ-brest.fr/hal-01517757
Contributeur : Maryline Beyler <>
Soumis le : mercredi 3 mai 2017 - 15:53:25
Dernière modification le : jeudi 20 septembre 2018 - 17:02:01

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Luís M. P. Lima, Maryline Beyler, Fatima Oukhatar, Patricia Le Saec, Alain Faivre-Chauvet, et al.. H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications. Chemical Communications, Royal Society of Chemistry, 2014, 50 (82), pp.12371 - 12374. 〈10.1039/C4CC05529B〉. 〈hal-01517757〉

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