H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications

Luís M. P. Lima; Maryline Beyler; Fatima Oukhatar; Patricia Le Saec; Alain Faivre-Chauvet; Carlos Platas-Iglesias; Rita Delgado; Raphaël Tripier

doi:10.1039/C4CC05529B

H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications

Luís M. P. Lima ¹ Maryline Beyler ² Fatima Oukhatar ² Patricia Le Saec ³ Alain Faivre-Chauvet ³ Carlos Platas-Iglesias ⁴ Rita Delgado ¹ Raphaël Tripier ²

1 ITQB - Instituto de Tecnologia Química e Biológica António Xavier

2 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique

3 CRCNA - Centre de Recherche en Cancérologie / Nantes - Angers

4 Departamento de Química Fundamental

Abstract : The complexation properties of H2Me-do2pa towards natBi3+ reveal a rather fast formation of the [Bi(Me-do2pa)]+ complex, which is endowed with a very high thermodynamic stability (log KBiL = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of H2Me-do2pa with 213Bi was performed and the resulting complex was stable in vitro, sustaining its use as an attractive alternative to H4dota taken here as a reference.

Keywords : coordination chemistry radiochemistry

Type de document :

Article dans une revue

Chemical Communications, Royal Society of Chemistry, 2014, 50 (82), pp.12371 - 12374. 〈10.1039/C4CC05529B〉

Domaine :

Chimie / Chimie de coordination

Chimie / Chimie organique

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http://hal.univ-brest.fr/hal-01517757
Contributeur : Maryline Beyler <>
Soumis le : mercredi 3 mai 2017 - 15:53:25
Dernière modification le : jeudi 20 septembre 2018 - 17:02:01

H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications

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H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications

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