Age, weight and decompression sickness in rats

Peter Buzzacott 1 Michael Theron 1 Aleksandra Mazur 1 Qiong Wang 1 Kate Lambrechts 1 Ingrid Eftedal 2 Simin Berenji Ardestani 2 François Guerrero 1, 3
1 EA 4324, Optimisation des Régulations PHYsiologiques
2 Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
3 UBO UFR SEP - Université de Bretagne Occidentale - UFR Sport et éducation physique
Abstract : Objective: The aim of this study was to determine if, after controlling for weight, age is associated with decompression sickness (DCS) in rats. Methods: Following compression-decompression, male rats aged 11 weeks were observed for DCS. After two weeks recovery surviving rats were re-dived using the same compression-decompression profile. Results: In this experiment there was a clear difference between DCS outcome at ages 11 or 13 weeks in matched rats (p=0.002). Discussion: Even with weight included in the model age was significantly associated with DCS (p=0.01), yet after removal of weight the association was much stronger (p=0.002). Conclusion: We believe that age is likely to be found associated with the probability of DCS in a larger dataset with a wider range of parameters, after accounting for the effect of weight.
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Archives of Physiology and Biochemistry, Informa Healthcare, 2016, 122 (2), pp.67 - 69. 〈10.3109/13813455.2016.1140787〉
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Peter Buzzacott, Michael Theron, Aleksandra Mazur, Qiong Wang, Kate Lambrechts, et al.. Age, weight and decompression sickness in rats. Archives of Physiology and Biochemistry, Informa Healthcare, 2016, 122 (2), pp.67 - 69. 〈10.3109/13813455.2016.1140787〉. 〈hal-01412101〉

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