Symptomatic Profiles of Patients With Polycythemia Vera: Implications of Inadequately Controlled Disease.

Holly Geyer; Robyn Scherber; Heidi Kosiorek; Amylou C Dueck; Jean-Jacques Kiladjian; Zhijian Xiao; Stefanie Slot; Sonja Zweegman; Federico Sackmann; Ana Kerguelen Fuentes; Dolores Hernández-Maraver; Konstanze Döhner; Claire N Harrison; Deepti Radia; Pablo Muxi; Carlos Besses; Francisco Cervantes; Peter L Johansson; Bjorn Andreasson; Alessandro Rambaldi; Tiziano Barbui; Karin Bonatz; Andreas Reiter; Francoise Boyer; Gabriel Etienne; Jean-Christophe Ianotto; Dana Ranta; Lydia Roy; Jean-Yves Cahn; Norman Maldonado; Giovanni Barosi; Maria L Ferrari; Robert Peter Gale; Gunnar Birgegard; Zefeng Xu; Yue Zhang; Xiujuan Sun; Junqing Xu; Peihong Zhang; Peter a W Te Boekhorst; Suzan Commandeur; Harry Schouten; Heike L Pahl; Martin Griesshammer; Frank Stegelmann; Thomas Lehmann; Zhenya Senyak; Alessandro M Vannucchi; Francesco Passamonti; Jan Samuelsson; Ruben A Mesa

doi:10.1200/JCO.2015.62.9337

Journal Articles Journal of Clinical Oncology Year : 2016

Symptomatic Profiles of Patients With Polycythemia Vera: Implications of Inadequately Controlled Disease.

, , , , (1, 2) , , , , , , , , , , , , , , , (3) , (4) , , , (5, 6) , (7) , (8, 9) , , , (10) , , , (11) , , (12) , (13) , , , (14) , (15) , , , , , , , , , , , ,

1
2
3
4
5
6
7
8
9
10
11
12
13
14
15

Holly Geyer

Function : Author

Robyn Scherber

Function : Author

Heidi Kosiorek

Function : Author

Amylou C Dueck

Function : Author

Jean-Jacques Kiladjian

Function : Author
PersonId : 761629
ORCID : 0000-0002-8121-438X
IdRef : 121011704

Hématologie -Immunologie -Cibles thérapeutiques

Centre d'Investigations Cliniques

Zhijian Xiao

Function : Author

Stefanie Slot

Function : Author

Sonja Zweegman

Function : Author

Federico Sackmann

Function : Author

Ana Kerguelen Fuentes

Function : Author

Dolores Hernández-Maraver

Function : Author

Konstanze Döhner

Function : Author

Claire N Harrison

Function : Author

Deepti Radia

Function : Author

Pablo Muxi

Function : Author

Carlos Besses

Function : Author

Francisco Cervantes

Function : Author

Peter L Johansson

Function : Author

Bjorn Andreasson

Function : Author

Alessandro Rambaldi

Function : Author
PersonId : 763388
ORCID : 0000-0002-3739-7502

Hematology and Bone Marrow Transplant Unit

Tiziano Barbui

Function : Author

Hematology

Karin Bonatz

Function : Author

Andreas Reiter

Function : Author

Francoise Boyer

Function : Author

Santé publique, vieillissement, qualité de vie et réadaptation des sujets fragiles - EA 3797

Service de Médecine Physique Neurologique-Traumatologique [Reims]

Gabriel Etienne

Function : Author
PersonId : 936615
ORCID : 0000-0001-7600-4954

Institut de pharmacologie et de biologie structurale

Jean-Christophe Ianotto

Function : Author

Institut de cancérologie et d'hématologie

Groupe d'Etude de la Thrombose de Bretagne Occidentale

Dana Ranta

Function : Author

Lydia Roy

Function : Author

Jean-Yves Cahn

Function : Author

TheREx

Norman Maldonado

Function : Author

Giovanni Barosi

Function : Author

Maria L Ferrari

Function : Author

Laboratoire Réactions et Génie des Procédés

Robert Peter Gale

Function : Author

Gunnar Birgegard

Function : Author

Department of Haematology, Division of Medicine, Institution for Medical Sciences

Zefeng Xu

Function : Author

Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes

Yue Zhang

Function : Author

Xiujuan Sun

Function : Author

Junqing Xu

Function : Author

Institute of Medicinal Plant Development

Peihong Zhang

Function : Author

State Key Laboratory of Rare Resource Utilization

Peter a W Te Boekhorst

Function : Author

Suzan Commandeur

Function : Author

Harry Schouten

Function : Author

Heike L Pahl

Function : Author

Martin Griesshammer

Function : Author

Frank Stegelmann

Function : Author

Thomas Lehmann

Function : Author

Zhenya Senyak

Function : Author

Alessandro M Vannucchi

Function : Author

Francesco Passamonti

Function : Author
PersonId : 769022
ORCID : 0000-0001-8068-5289

Jan Samuelsson

Function : Author

Ruben A Mesa

Function : Author

Abstract

Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) associated with disabling symptoms and a heightened risk of life-threatening complications. Recent studies have demonstrated the effectiveness of JAK inhibitor therapy in patients with PV patients who have a history of prior hydroxyurea (HU) use (including resistance or intolerance), phlebotomy requirements, and palpable splenomegaly. We aimed to determine how these features contribute alone and in aggregate to the PV symptom burden. Through prospective evaluation of 1,334 patients with PV who had characterized symptom burden, we assessed patient demographics, laboratory data, and the presence of splenomegaly by disease feature (ie, known HU use, known phlebotomy requirements, splenomegaly). The presence of each feature in itself is associated with a moderately high symptom burden (MPN symptom assessment form [SAF] total symptom score [TSS] range, 27.7 to 29.2) that persists independent of PV risk category. In addition, symptoms incrementally increase in severity with the addition of other features. Patients with PV who had all three features (PV-HUPS) faced the highest total score (MPN-SAF TSS, 32.5) but had similar individual symptom scores to patients with known HU use (PV-HU), known phlebotomy (PV-P), and splenomegaly (PV-S). The results of this study suggest that patients with PV who have any one of the features in question (known HU use, known phlebotomy, or splenomegaly) have significant PV-associated symptoms. Furthermore, it demonstrates that many PV symptoms remain severe independent of the number of features present.

Keywords

Polycythemia Vera Symptomatic Profiles

Domains

Human health and pathology Life Sciences [q-bio]

Ghislaine Calvez : Connect in order to contact the contributor

https://hal.univ-brest.fr/hal-01276589

Submitted on : Friday, February 19, 2016-4:11:17 PM

Last modification on : Wednesday, October 16, 2024-1:49:31 PM

Dates and versions

hal-01276589 , version 1 (19-02-2016)

Identifiers

HAL Id : hal-01276589 , version 1
DOI : 10.1200/JCO.2015.62.9337
PUBMED : 26598745

Cite

Holly Geyer, Robyn Scherber, Heidi Kosiorek, Amylou C Dueck, Jean-Jacques Kiladjian, et al.. Symptomatic Profiles of Patients With Polycythemia Vera: Implications of Inadequately Controlled Disease.. Journal of Clinical Oncology, 2016, 34 (2), pp.151-9. ⟨10.1200/JCO.2015.62.9337⟩. ⟨hal-01276589⟩

Export

BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite

Collections

UNIV-BREST UNIV-PARIS7 UPMC UGA IMAG CNRS URCA GETBO TIMC-IMAG TIMC-IMAG-THEREX LBMCE UNIV-LORRAINE LRGP-UL USPC LMR VIEFRA CAPSANTE SORBONNE-UNIVERSITE IBSAM SU-SCIENCES IPBS UNIV-UT3 UT3-TOULOUSEINP EMPP-UL

2096 View

0 Download

Symptomatic Profiles of Patients With Polycythemia Vera: Implications of Inadequately Controlled Disease.

Abstract

Keywords

Domains

Dates and versions

Identifiers

Cite

Export

Collections

Altmetric

Share