Transcriptome analysis of bone marrow mesenchymal stromal cells from patients with primary myelofibrosis.

Christophe Martinaud 1, 2, 3, 4 Christophe Desterke 3, 4 Johanna Konopacki 5 Alessandro M Vannucchi 6 Lisa Pieri Paola Guglielmelli 7 Brigitte Dupriez 8 Jean-Christophe Ianotto 9, 10 Laetitia Boutin Jean-Jacques Lataillade 4, 11 Marie-Caroline Le Bousse-Kerdilès 1, 3, 4
1 FIM
2 Département de biologie clinique
3 SFR89
4 Interactions cellules souches-niches : physiologie, tumeurs et réparation tissulaire
5 Département d'hématologie
6 MPN-CRIMM
7 The Department of Hematology
8 Département d'hématologie
9 Institut de cancérologie et d'hématologie
10 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
11 IRBA - Institut de Recherche Biomédicale des Armées
Abstract : Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm whose severity and treatment complexity are attributed to the presence of bone marrow (BM) fibrosis and alterations of stroma impairing the production of normal blood cells. Despite the recently discovered mutations including the JAK2V617F mutation in about half of patients, the primitive event responsible for the clonal proliferation is still unknown. In the highly inflammatory context of PMF, the presence of fibrosis associated with a neoangiogenesis and an osteosclerosis concomitant to the myeloproliferation and to the increase number of circulating hematopoietic progenitors suggests that the crosstalk between hematopoietic and stromal cells is deregulated in the PMF BM microenvironmental niches. Within these niches, mesenchymal stromal cells (BM-MSC) play a hematopoietic supportive role in the production of growth factors and extracellular matrix which regulate the proliferation, differentiation, adhesion and migration of hematopoietic stem/progenitor cells. A transcriptome analysis of BM-MSC in PMF patients will help to characterize their molecular alterations and to understand their involvement in the hematopoietic stem/progenitor cell deregulation that features PMF.
Keywords : Myeloproliferative disorders Mesenchymal stroma cells Bone marrow Primary myelofibrosis
Type de document :
Article dans une revue
Genomics Data, Elsevier, 2015, 5, pp.1-2. 〈10.1016/j.gdata.2015.04.017〉
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http://hal.univ-brest.fr/hal-01275279
Contributeur : Ghislaine Calvez <>
Soumis le : mercredi 17 février 2016 - 11:14:47
Dernière modification le : lundi 22 janvier 2018 - 11:36:06

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UNIV-BREST | SSA | GETBO | UNIV-PARIS-SACLAY

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Christophe Martinaud, Christophe Desterke, Johanna Konopacki, Alessandro M Vannucchi, Lisa Pieri, et al.. Transcriptome analysis of bone marrow mesenchymal stromal cells from patients with primary myelofibrosis.. Genomics Data, Elsevier, 2015, 5, pp.1-2. 〈10.1016/j.gdata.2015.04.017〉. 〈hal-01275279〉

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