Interpretation of suspect head and neck fixations seen on PET/CT in lung cancer.

Y Gobel 1 G Valette 2, 1 R Abgral 3, 4 C Clodic 1 E Mornet 1 G Potard 2, 1 P-Y Salaun 4, 3 R Marianowski 1
1 Department of ORL
2 LaTIM - Laboratoire de Traitement de l'Information Medicale
3 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
4 Department of Nuclear Medicine
Abstract : Smoking is the major risk factor for lung and head and neck cancer. The purpose of the present study was to determine the clinical impact of serendipitously revealed head and neck fixation on PET/CT in patients undergoing investigation for lung cancer. The reports from PET/CT studies for patients with lung cancer from September 2005 and April 2012 were retrospectively reviewed. Head and neck incidentaloma was interpreted as suggestive of second primary malignancy. These incidental findings were compared with the final diagnosis obtained from clinical and histological investigation. Five hundred and ninety-two patients were investigated on PET/CT for lung cancer in the study period. PET/CT-positive head and neck lesions suggestive of second primary malignancy were found in 65 (11%) patients. Nasoendoscopy was performed in 23 patients and biopsy in 10. In 4 patients (17.4% of those explored), a second primary malignant lesion was proved on histology: 2 squamous cell carcinomas (larynx and oral cavity), 1 undifferentiated carcinoma (parotid), and 1 osteosarcoma (mandible). At a median 13 months' follow-up, 3 of the 4 patients with a second primary had died from disease-related causes and 1 was free of recurrence. Metastases from lung adenocarcinoma were found in 2 patients (0.34%). PET/CT detected incidental head and neck malignant tumors in at least 0.68% of lung cancer patients, but in 6.4% of those with suspect head and neck fixation.
Keywords : Incidentaloma PET/CT Head and neck cancer Lung cancer Second malignancy
Type de document :
Article dans une revue
European Archives of Oto-Rhino-Laryngology, Springer Verlag, 2014, 131 (4), pp.217-21. 〈10.1016/j.anorl.2013.06.004〉
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http://hal.univ-brest.fr/hal-01256583
Contributeur : Ghislaine Calvez <>
Soumis le : vendredi 15 janvier 2016 - 09:32:46
Dernière modification le : mardi 16 janvier 2018 - 15:54:12

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Y Gobel, G Valette, R Abgral, C Clodic, E Mornet, et al.. Interpretation of suspect head and neck fixations seen on PET/CT in lung cancer.. European Archives of Oto-Rhino-Laryngology, Springer Verlag, 2014, 131 (4), pp.217-21. 〈10.1016/j.anorl.2013.06.004〉. 〈hal-01256583〉

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