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Long-term efficacy of infliximab in autoimmune sensorineural hearing loss associated with rheumatoid arthritis.

Abstract : Systemic lupus erythematosus (SLE) disease is an autoimmune disease of unknown aetiology that affects predominantly women of child bearing age. Since previous studies, including ours, have demonstrated that CD4+ T cells and B cells from SLE patients are defective in their ability to methylate their DNA upon antigen stimulation, the aim of this study was to investigate whether DNA demethylation affects the transcription of HRES-1 in B cells. HRES-1 is the prototype of Human Endogenous Retrovirus (HERV) overexpressed in SLE. We have observed that SLE B cells were characterized by their incapacity to methylate the HRES-1 promoter, both in unstimulated and in anti-IgM stimulated B cells. In turn, HRES-1/p28 expression was increased in SLE B cells after B cell receptor engagement, but not in controls. In SLE B cells the Erk/DNMT1 pathway was defective. In addition, blocking the autocrine-loop of IL-6 in SLE B cells with an anti-IL-6 receptor monoclonal antibody restores DNA methylation and control of HRES-1/p28 expression became effective. As a consequence, a better understanding of HERV dysregulation in SLE reinforces our comprehension of the disease and opens new therapeutic perspectives.
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https://hal.univ-brest.fr/hal-01128902
Contributor : Geneviève Michel <>
Submitted on : Tuesday, March 10, 2015 - 3:30:21 PM
Last modification on : Wednesday, March 11, 2015 - 1:05:55 AM

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  • HAL Id : hal-01128902, version 1
  • PUBMED : 24625506

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Pierre Gazeau, Alain Saraux, Valérie Devauchelle-Pensec, Divi Cornec. Long-term efficacy of infliximab in autoimmune sensorineural hearing loss associated with rheumatoid arthritis.. Rheumatology, Oxford University Press (OUP), 2014, 53 (9), pp.1715-6. ⟨hal-01128902⟩

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