Exopolysaccharides isolated from hydrothermal vent bacteria can modulate the complement system.

Abstract : The complement system is involved in the defence against bacterial infection, or in the elimination of tumour cells. However, disturbances in this system contributes to the pathogenesis of various inflammatory diseases. The efficiency of therapeutic anti-tumour antibodies is enhanced when the complement system is stimulated. In contrast, cancer cells are able to inhibit the complement system and thus proliferate. Some marine molecules are currently being developed as new drugs for use in humans. Among them, known exopolyssacharides (EPSs) generally originate from fungi, but few studies have been performed on bacterial EPSs and even fewer on EPSs extracted from deep-sea hydrothermal vent microbes. For use in humans, these high molecular weight EPSs must be depolymerised. Furthermore, the over-sulphation of EPSs can modify their biological activity. The aim of this study was to investigate the immunodulation of the complement system by either native or over-sulphated low molecular weight EPSs isolated from vent bacteria in order to find pro or anti-activators of complement.
Type de document :
Article dans une revue
PLoS ONE, Public Library of Science, 2013, 9 (4), pp.e94965. 〈http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094965〉
Liste complète des métadonnées

Littérature citée [43 références]  Voir  Masquer  Télécharger

http://hal.univ-brest.fr/hal-01128892
Contributeur : Geneviève Michel <>
Soumis le : jeudi 4 février 2016 - 09:40:15
Dernière modification le : mardi 6 mars 2018 - 17:12:01
Document(s) archivé(s) le : samedi 12 novembre 2016 - 07:34:48

Fichier

journal.pone.0094965.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Anthony Courtois, Christian Berthou, Jean Guézennec, Claire Boisset, Anne Bordron. Exopolysaccharides isolated from hydrothermal vent bacteria can modulate the complement system.. PLoS ONE, Public Library of Science, 2013, 9 (4), pp.e94965. 〈http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094965〉. 〈hal-01128892〉

Partager

Métriques

Consultations de la notice

140

Téléchargements de fichiers

97