Antifouling compounds from the sub-arctic ascidian Synoicum pulmonaria: synoxazolidinones A and C, pulmonarins A and B, and synthetic analogues.

Rozenn Trepos 1 Gunnar Cervin 2 Claire Hellio 3, 1 Henrik Pavia 2 Wenche Stensen 4 Klara Stensvåg 5 John-Sigurd Svendsen 6 Tor Haug 5 Johan Svenson 6
1 School of Biological Sciences
2 GU - University of Gothenburg
3 LEMAR - Laboratoire des Sciences de l'Environnement Marin (LEMAR)
4 Lytix Biopharma
5 Norwegian College of Fishery Science
6 UiT - University of Tromsø
Abstract : The current study describes the antifouling properties of four members belonging to the recently discovered synoxazolidinone and pulmonarin families, isolated from the sub-Arctic sessile ascidian Synoicum pulmonaria collected off the Norwegian coast. Four simplified synthetic analogues were also prepared and included in the study. Several of the studied compounds displayed MIC values in the micro-nanomolar range against 16 relevant marine species involved in both the micro- and macrofouling process. Settlement studies on Balanus improvisus cyprids indicated a deterrent effect and a low toxicity for selected compounds. The two synoxazolidinones displayed broad activity and are shown to be among the most active natural antifouling bromotyrosine derivatives described. Synoxazolidinone C displayed selected antifouling properties comparable to the commercial antifouling product Sea-Nine-211. The pulmonarins prevented the growth of several bacterial strains at nanomolar concentrations but displayed a lower activity toward microalgae and no effect on barnacles. The linear and cyclic synthetic peptidic mimics also displayed potent antifouling activities mainly directed against bacterial adhesion and growth.
Keywords : AQUACULTURE ENVIRONMENT COATINGS 4-OXAZOLIDINONES SPONGE GEODIA-BARRETTI MARINE NATURAL-PRODUCTS BARNACLE BALANUS-IMPROVISUS SECONDARY METABOLITES FUTURE ALKALOIDS
Type de document :
Article dans une revue
Journal of Natural Products, American Chemical Society, 2014, 77 (9), pp.2105-2113
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http://hal.univ-brest.fr/hal-01103850
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Soumis le : jeudi 15 janvier 2015 - 15:05:59
Dernière modification le : jeudi 11 janvier 2018 - 06:22:24

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  • HAL Id : hal-01103850, version 1
  • PUBMED : 25181423

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Rozenn Trepos, Gunnar Cervin, Claire Hellio, Henrik Pavia, Wenche Stensen, et al.. Antifouling compounds from the sub-arctic ascidian Synoicum pulmonaria: synoxazolidinones A and C, pulmonarins A and B, and synthetic analogues.. Journal of Natural Products, American Chemical Society, 2014, 77 (9), pp.2105-2113. 〈hal-01103850〉

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