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Are the B cells cast with the leading part in the Sjogren's syndrome scenario?

Abstract : The autoimmune exocrinopathy Sjögren's syndrome (SS) is characterized by mononuclear cell (MNC) infiltrates of exocrine glands and overactivity of B lymphocytes. Although T cells have long been perceived as the prime effectors, increasing evidence indicates that the key role is rather served by B cells. Among related abnormalities are rheumatoid factor (RF), anti-SSA/Ro, and anti-SSB/La antibodies (Ab). Also, supporting this view is our finding of an increase in the number of circulating naïve mature B (Bm) cells, with a reciprocal decrease in that of memory B cells. Furthermore, a ratio of Bm2-plus-Bm2' cells to early Bm5-plus-late Bm5 above 5 is diagnostic. This variation partly reflects the migration of active memory B cells into the exocrine glands of the patients, as well as into their skin. More recently, the B-cell-activating factor of the TNF family (BAFF) has been endorsed with a pivotal role in B-cell survival and hence implicated in the pathogenesis of autoimmunity. In practice, B cells have turned quite attractive as a target for biotherapy. For example, treatment with anti-CD20 Ab has afforded some benefits in this disease, while BAFF blockers are still on the way, but should expand our armamentarium for treating SS. With such B-cell-directed biotherapies in mind, we delineate herein the distinguishing traits of B lymphocytes in SS.
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Contributor : Geneviève Michel Connect in order to contact the contributor
Submitted on : Friday, September 5, 2014 - 2:54:50 PM
Last modification on : Monday, March 28, 2022 - 12:10:05 PM

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J.-O. Pers, P. Youinou. Are the B cells cast with the leading part in the Sjogren's syndrome scenario?. Oral Diseases, 2014, 20 (6), pp.529-37. ⟨10.1111/odi.12153⟩. ⟨hal-01061308⟩



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