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[Regulatory lymphocytes: a new cooperation between T and B cells for a better control of the immune response].

Abstract : Mechanims of peripheral tolerance include molecular controls and the presence of regulatory lymphocytes. Regulatory T lymphocytes (Tregs) correspond to different sub-populations of T cells that control immune responses due to the production of cytokines, such as IL-10 and with direct cell-to-cell contacts. Tregs targets are antigen presenting cells, such as dendritic cells, effector CD4(+) and CD8(+) lymphocytes but also effector antibody-producing B lymphocytes. Regulatory B lymphocytes (Bregs) have been more recently described and likely represent different sub-populations of B cells that control the development of autoimmune and inflammatory diseases due to the production of IL-10 and using intercellular contacts. Bregs targets encompass all the cells involved in the immune responses which are thus under a dual control by regulatory lymphocytes. Development and efficient activity of Tregs appear dependent of Bregs for a better regulation of autoimmune reactions, of anti-infectious reactions, but also of anti-tumor reactions.
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Submitted on : Monday, March 10, 2014 - 12:16:58 PM
Last modification on : Wednesday, September 7, 2022 - 11:32:04 AM




Jamin Christophe, Achouak Achour, Pierre Youinou, Jacques-Olivier Pers. [Regulatory lymphocytes: a new cooperation between T and B cells for a better control of the immune response].. La Presse medicale, 2014, 43 (1), pp.18-26. ⟨10.1016/j.lpm.2013.02.332⟩. ⟨hal-00957388⟩



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