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B cells display an abnormal distribution and an impaired suppressive function in patients with chronic antibody-mediated rejection.

Abstract : In kidney transplantation, the composition of the B-cell compartment is increasingly identified as an important determinant for graft outcome. Whereas naive and transitional B cells have been associated with long-term allograft survival and operational tolerance, memory B cells have been linked to graft rejection and graft loss. Chronic antibody-mediated rejection now represents a major complication in transplantation and is a challenge in current therapeutics. Here, we show that patients with chronic antibody-mediated rejection display a unique B-cell phenotype with a reduced ratio of activated to memory B cells associated with an impaired immunosuppressive activity. The regulatory functions of the B cells depended on their maturation status. Thus, phenotypic and functional analyses of the B-cell compartment may be indicated for appropriate follow-up after transplantation and drive therapy in the establishment of transplant tolerance processes.
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https://hal.univ-brest.fr/hal-00955526
Contributor : Geneviève Michel <>
Submitted on : Tuesday, March 4, 2014 - 4:03:31 PM
Last modification on : Thursday, March 5, 2020 - 6:38:43 PM

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Alexandre Nouël, Isabelle Ségalen, Christophe Jamin, Laurent Doucet, Sophie Caillard, et al.. B cells display an abnormal distribution and an impaired suppressive function in patients with chronic antibody-mediated rejection.. Kidney International, Nature Publishing Group, 2014, 85 (3), pp.590-9. ⟨10.1038/ki.2013.457⟩. ⟨hal-00955526⟩

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