B cells display an abnormal distribution and an impaired suppressive function in patients with chronic antibody-mediated rejection.

Alexandre Nouël; Isabelle Ségalen; Christophe Jamin; Laurent Doucet; Sophie Caillard; Yves Renaudineau; Jacques-Olivier Pers; Yannick Le Meur; Sophie Hillion

doi:10.1038/ki.2013.457

B cells display an abnormal distribution and an impaired suppressive function in patients with chronic antibody-mediated rejection.

Alexandre Nouël ^{1, 2} Isabelle Ségalen ^{2, 1} Christophe Jamin ^{2, 1} Laurent Doucet ³ Sophie Caillard ^{2, 4, 1} Yves Renaudineau ^{2, 5, 1} Jacques-Olivier Pers ^{2, 1} Yannick Le Meur ^{2, 6, 1} Sophie Hillion ^{2, 1}

1 LabEX IGO Immunothérapie Grand Ouest

2 EA2216 - Immunologie et Pathologie

3 CHU - AnaPath - CHRU Brest - Laboratoire d'Anatomo-Pathologie

4 Service de néphrologie

5 Laboratoire d'Immunologie et Immunothérapie

6 Service de Néphrologie

Abstract : In kidney transplantation, the composition of the B-cell compartment is increasingly identified as an important determinant for graft outcome. Whereas naive and transitional B cells have been associated with long-term allograft survival and operational tolerance, memory B cells have been linked to graft rejection and graft loss. Chronic antibody-mediated rejection now represents a major complication in transplantation and is a challenge in current therapeutics. Here, we show that patients with chronic antibody-mediated rejection display a unique B-cell phenotype with a reduced ratio of activated to memory B cells associated with an impaired immunosuppressive activity. The regulatory functions of the B cells depended on their maturation status. Thus, phenotypic and functional analyses of the B-cell compartment may be indicated for appropriate follow-up after transplantation and drive therapy in the establishment of transplant tolerance processes.

Type de document :

Article dans une revue

Kidney International, Nature Publishing Group, 2014, 85 (3), pp.590-9. 〈10.1038/ki.2013.457〉

Domaine :

Sciences du Vivant [q-bio] / Immunologie

Liste complète des métadonnées

http://hal.univ-brest.fr/hal-00955526
Contributeur : Geneviève Michel <>
Soumis le : mardi 4 mars 2014 - 16:03:31
Dernière modification le : lundi 26 mars 2018 - 14:51:24

B cells display an abnormal distribution and an impaired suppressive function in patients with chronic antibody-mediated rejection.

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B cells display an abnormal distribution and an impaired suppressive function in patients with chronic antibody-mediated rejection.

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