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Outpatient treatment of symptomatic pulmonary embolism: a systematic review and meta-analysis.

Abstract : BACKGROUND: Patients with acute deep vein thrombus (DVT) can safely be treated as outpatients. However the role of outpatient treatment in patients diagnosed with a pulmonary embolism (PE) is controversial. We sought to determine the safety of outpatient management of patients with acute symptomatic PE. MATERIALS AND METHODS: A systematic literature search strategy was conducted using MEDLINE, EMBASE, the Cochrane Register of Controlled Trials and all EBM Reviews. Pooled proportions for the different outcomes were calculated. RESULTS: A total of 1258 patients were included in the systematic review. The rate of recurrent venous thromboembolism (VTE) in patients with PE managed as outpatients was 1.47% (95% CI: 0.47 to 3.0%; I(2): 65.4%) during the 3 month follow-up period. The rate of fatal PE was 0.47% (95% CI: 0.16 to 1.0%; I(2): 0%). The rates of major bleeding and fatal intracranial hemorrhage were 0.81% (95% CI: 0.37 to 1.42%; I(2): 0%) and 0.29% (95% CI: 0.06 to 0.68%; I(2): 0%), respectively. The overall 3 month mortality rate was 1.58% (95% CI: 0.71 to 2.80%; I(2): 45%). The event rates were similar if employing risk stratification models versus using clinical gestalt to select appropriate patients for outpatient management. CONCLUSIONS: Independent of the risk stratification methods used, the rate of adverse events associated with outpatient PE treatment seems low. Based on our systematic review and pooled meta-analysis, low-risk patients with acute PE can safely be treated as outpatients if home circumstances are adequate.
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https://hal.univ-brest.fr/hal-00935491
Contributor : Ghislaine Calvez <>
Submitted on : Thursday, January 23, 2014 - 3:42:30 PM
Last modification on : Thursday, February 7, 2019 - 2:50:13 PM

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Siavash Piran, Grégoire Le Gal, Philip S Wells, Esteban Gandara, Marc Righini, et al.. Outpatient treatment of symptomatic pulmonary embolism: a systematic review and meta-analysis.. Thrombosis Research, Elsevier, 2013, 132 (5), pp.515-9. ⟨10.1016/j.thromres.2013.08.012⟩. ⟨hal-00935491⟩

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