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Usefulness of omalizumab in ten patients with severe occupational asthma.

Abstract : BACKGROUND: The management of severe occupational asthma (OA) remains problematic and new alternative treatments providing better disease control are required, ideally enabling affected individuals to remain in their job. METHODS: Ten patients with severe uncontrolled OA were treated with the monoclonal anti-IgE antibody omalizumab. In six cases the causative agent was a high molecular weight (HMW) compound and in four cases it was a low molecular weight (LMW) chemical. All of the patients had well documented OA despite workplace adjustments. RESULTS: During treatment, nine patients exhibited a lower rate of asthma exacerbations and used less oral or inhaled corticosteroids. Seven patients were able to continue working at the same workplace as before treatment. CONCLUSION: We have demonstrated that omalizumab is a potential treatment for severe uncontrolled OA and enabled seven of the ten patients in the study to remain in their job.
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https://hal.univ-brest.fr/hal-00935134
Contributor : Ghislaine Calvez <>
Submitted on : Thursday, January 23, 2014 - 10:35:16 AM
Last modification on : Thursday, September 17, 2020 - 8:36:03 AM

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François Lavaud, P. Bonniaud, J. C. Dalphin, Christophe Leroyer, D. Muller, et al.. Usefulness of omalizumab in ten patients with severe occupational asthma.. Allergy, Wiley, 2013, 68 (6), pp.813-5. ⟨10.1111/all.12149⟩. ⟨hal-00935134⟩

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