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Journal articles
Non-OO blood type influences the risk of recurrent venous thromboembolism. A cohort study.
Esteban Gándara
1, 2
Michael J Kovacs
3
Susan R Kahn
4, 5
Philip S Wells
1, 6
David A Anderson
7
Isabelle Chagnon
8
Grégoire Le Gal
9, 10
Susan Solymoss
4
Mark Crowther
11
Marc Carrier
1, 2
Nicole Langlois
12
Judy Kovacs
3
Julian Little Ma
13
Nancy Carson
14
Tim Ramsay
1, 2
Marc A Rodger
1, 2, *
*
Corresponding author
Esteban Gándara 1, 2
Author
Michael J Kovacs 3
Author
Susan R Kahn 4, 5
Author
Philip S Wells 1, 6
Author
David A Anderson 7
Author
Isabelle Chagnon 8
Author
Grégoire Le Gal 9, 10
Author
Susan Solymoss 4
Author
Julian Little Ma 13
Author
Nancy Carson 14
Author
Tim Ramsay 1, 2
Author
Marc A Rodger 1, 2
Correspondent author
1
Clinical Epidemiology Unit (Ottawa Hospital Research Institute - Canada)
- Ottawa (France)
- The Ottawa Hospital (France)
2
Thrombosis Program (Division of Hematology Department of Medicine - Canada)
- uOttawa - University of Ottawa [Ottawa] (75 Laurier Avenue East, Ottawa, ON K1N 6N5 - Canada)
3
LONDON ONTARIO - Med - Department of Medicine (Department of Medicine, University of Western Ontario, London, Ontario, Canada - Canada)
- UWO - University of Western Ontario (1151 Richmond St, London, ON, N6A 3K7, Canada - Canada)
4
Department of Medecine [Montréal] (McGill University McIntyre Medical Building, 3655 Sir William Osler Montreal, Quebec H3G 1Y6 - Canada)
- McGill University = Université McGill [Montréal, Canada] (845, rue Sherbrooke O. Montréal (Québec) Canada H3A 0G4 - Canada)
5
CCECS - Centre for Clinical Epidemiology and Community Studies (MONTREAL - Canada)
- Jewish General Hospital (Canada)
6
Thrombosis Program (Division of Hematology Department of Medicine - France)
- uOttawa - University of Ottawa [Ottawa] (75 Laurier Avenue East, Ottawa, ON K1N 6N5 - Canada)
7
Department of Medicine (HALIFAX - Canada)
- Dalhousie University [Halifax] ( 6299 South St, Halifax, NS B3H 4R2 - Canada)
8
Department of Medicine (Hôpital du Sacré Coeur de Montréal - France)
- University of Montreal (France)
9
GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale (CHU de la Cavale Blanche Département de médecine interne et pneumologie 29609 BREST - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
- IBSAM - Institut Brestois Santé Agro Matière (Université de Brest- UBO
29238 Brest - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
10
CIC - Brest - Centre d'Investigation Clinique (CHU de la Cavale Blanche 29609 Brest - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : CIC502 (101, rue de Tolbiac, 75013 Paris - France)
11
Department of Medicine (Michael G. DeGroote School of Medicine Hamilton - France)
- McMaster University [Hamilton, Ontario] (1280 Main Street West Hamilton, Ontario L8S 4L8 - Canada)
12
IMN - Institut des Matériaux Jean Rouxel (Campus Sciences 2 Rue de la Houssinière - BP 32229 44322 NANTES CEDEX 3 - France)
- UN - Université de Nantes (1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR6502 (France)
13
OTTAWA - Epidemio - Department of Epidemiology and Community Medicine (Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada - Canada)
- uOttawa - University of Ottawa [Ottawa] (75 Laurier Avenue East, Ottawa, ON K1N 6N5 - Canada)
14
OTTAWA - Pedia - Department of Pediatrics (Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada - Canada)
- uOttawa - University of Ottawa [Ottawa] (75 Laurier Avenue East, Ottawa, ON K1N 6N5 - Canada)
Abstract : The role of ABO blood type as a risk factor for recurrent venous thromboembolism (VTE) in patients with a first unprovoked VTE who complete oral anticoagulation therapy is unknown. The aim of this study was to determine if non-OO blood type is a risk factor for recurrent VTE in patients with a first unprovoked VTE who completed 5-7 months of anticoagulant therapy. In an ongoing cohort study of patients with unprovoked VTE who discontinued oral anticoagulation after 5-7 months of therapy, six single nucleotide polymorphisms sites were tested to determine ABO blood type using banked DNA. The main outcome was objectively proven recurrent VTE. Mean follow-up for the cohort was 4.19 years (SD 2.16). During 1,553 patient-years of follow-up, 101 events occurred in 380 non-OO patients (6.5 events per 100 patient years; 95% CI 5.3-7.7) compared to 14 events during 560 patient years of follow-up in 129 OO patients (2.5 per 100 patient years; 95% CI 1.2-3.7), the adjusted hazard ratio was 1.98 (1.2-3.8). In conclusion, non-OO blood type is associated with a statistically significant and clinically relevant increased risk of recurrent VTE following discontinuation of anticoagulant therapy for a first episode of unprovoked VTE.
Document type :
Journal articles
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Complete list of metadatas
https://hal.univ-brest.fr/hal-00934053
Contributor : Ghislaine Calvez <>
Submitted on : Tuesday, January 21, 2014 - 3:08:28 PM
Last modification on : Thursday, June 18, 2020 - 12:32:04 PM
Contributor : Ghislaine Calvez <>
Submitted on : Tuesday, January 21, 2014 - 3:08:28 PM
Last modification on : Thursday, June 18, 2020 - 12:32:04 PM
Identifiers
- HAL Id : hal-00934053, version 1
- DOI : 10.1160/TH13-06-0488
- PUBMED : 24067945
Collections
CNRS | UNIV-NANTES | IMN | UNIV-BREST | GETBO | INC-CNRS | IBSAM
Citation
Esteban Gándara, Michael J Kovacs, Susan R Kahn, Philip S Wells, David A Anderson, et al.. Non-OO blood type influences the risk of recurrent venous thromboembolism. A cohort study.. Thrombosis and Haemostasis, Schattauer, 2013, 110 (6), pp.1172-9. ⟨10.1160/TH13-06-0488⟩. ⟨hal-00934053⟩
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