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Non-OO blood type influences the risk of recurrent venous thromboembolism. A cohort study.

Esteban Gándara 1, 2 Michael J Kovacs 3 Susan R Kahn 4, 5 Philip S Wells 1, 6 David A Anderson 7 Isabelle Chagnon 8 Grégoire Le Gal 9, 10 Susan Solymoss 4 Mark Crowther 11 Marc Carrier 1, 2 Nicole Langlois 12 Judy Kovacs 3 Julian Little Ma 13 Nancy Carson 14 Tim Ramsay 1, 2 Marc A Rodger 1, 2, *
* Corresponding author
1 Clinical Epidemiology Unit
2 Thrombosis Program
3 LONDON ONTARIO - Med - Department of Medicine
4 Department of Medecine [Montréal]
5 CCECS - Centre for Clinical Epidemiology and Community Studies
6 Thrombosis Program
7 Department of Medicine
8 Department of Medicine
9 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
10 CIC - Brest - Centre d'Investigation Clinique
11 Department of Medicine
12 IMN - Institut des Matériaux Jean Rouxel
13 OTTAWA - Epidemio - Department of Epidemiology and Community Medicine
14 OTTAWA - Pedia - Department of Pediatrics
Abstract : The role of ABO blood type as a risk factor for recurrent venous thromboembolism (VTE) in patients with a first unprovoked VTE who complete oral anticoagulation therapy is unknown. The aim of this study was to determine if non-OO blood type is a risk factor for recurrent VTE in patients with a first unprovoked VTE who completed 5-7 months of anticoagulant therapy. In an ongoing cohort study of patients with unprovoked VTE who discontinued oral anticoagulation after 5-7 months of therapy, six single nucleotide polymorphisms sites were tested to determine ABO blood type using banked DNA. The main outcome was objectively proven recurrent VTE. Mean follow-up for the cohort was 4.19 years (SD 2.16). During 1,553 patient-years of follow-up, 101 events occurred in 380 non-OO patients (6.5 events per 100 patient years; 95% CI 5.3-7.7) compared to 14 events during 560 patient years of follow-up in 129 OO patients (2.5 per 100 patient years; 95% CI 1.2-3.7), the adjusted hazard ratio was 1.98 (1.2-3.8). In conclusion, non-OO blood type is associated with a statistically significant and clinically relevant increased risk of recurrent VTE following discontinuation of anticoagulant therapy for a first episode of unprovoked VTE.
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https://hal.univ-brest.fr/hal-00934053
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Submitted on : Tuesday, January 21, 2014 - 3:08:28 PM
Last modification on : Monday, October 11, 2021 - 2:23:06 PM

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CNRS | UNIV-NANTES | IMN | UNIV-BREST | GETBO | INC-CNRS | IBSAM

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Esteban Gándara, Michael J Kovacs, Susan R Kahn, Philip S Wells, David A Anderson, et al.. Non-OO blood type influences the risk of recurrent venous thromboembolism. A cohort study.. Thrombosis and Haemostasis, Schattauer, 2013, 110 (6), pp.1172-9. ⟨10.1160/TH13-06-0488⟩. ⟨hal-00934053⟩

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