The cytotoxic effect of combined hyperthermia and taxane chemotherapy on ovarian cancer cells: results of an in vitro study.

Matthieu Muller 1 M. Chérel 2 Pierre-François Dupré 1 S. Gouard M. Collet 1, 3 J.-M. Classe
1 BREST - Gynéco-Obs - Service de Gynécologie-Obstétrique
2 CRCNA - Centre de Recherche en Cancérologie / Nantes - Angers
3 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
Abstract : PURPOSE: Hyperthermic intraperitoneal chemotherapy (HIPEC) is under continuous evaluation as a potential treatment for ovarian cancer. The purpose of this study was to evaluate the effect of chemotherapy, drug concentration and temperature. MATERIALS AND METHODS: We examined the combined effects of hyperthermia and taxane chemotherapy on the clonogenic survival of the human ovarian carcinoma SHIN-3 cell line in vitro. RESULTS: When hyperthermia was combined with chemotherapy, the median lethal dose (LD50) was equivalent regardless of the duration of exposure, and was independent of the exposure temperature. Taxanes showed a similar LD50 over the temperature range tested. CONCLUSIONS: In our study, hyperthermia does not increase the cytotoxic effects of taxanes, at least for the concentrations and durations tested.
Type de document :
Article dans une revue
European Surgical Research, Karger, 2012, 48 (2), pp.55-63. 〈10.1159/000333393〉
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http://hal.univ-brest.fr/hal-00932168
Contributeur : Ghislaine Calvez <>
Soumis le : jeudi 16 janvier 2014 - 14:20:38
Dernière modification le : jeudi 15 mars 2018 - 14:10:54

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UNIV-BREST | GETBO | CRCNA

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Matthieu Muller, M. Chérel, Pierre-François Dupré, S. Gouard, M. Collet, et al.. The cytotoxic effect of combined hyperthermia and taxane chemotherapy on ovarian cancer cells: results of an in vitro study.. European Surgical Research, Karger, 2012, 48 (2), pp.55-63. 〈10.1159/000333393〉. 〈hal-00932168〉

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