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The cytotoxic effect of combined hyperthermia and taxane chemotherapy on ovarian cancer cells: results of an in vitro study.

Abstract : PURPOSE: Hyperthermic intraperitoneal chemotherapy (HIPEC) is under continuous evaluation as a potential treatment for ovarian cancer. The purpose of this study was to evaluate the effect of chemotherapy, drug concentration and temperature. MATERIALS AND METHODS: We examined the combined effects of hyperthermia and taxane chemotherapy on the clonogenic survival of the human ovarian carcinoma SHIN-3 cell line in vitro. RESULTS: When hyperthermia was combined with chemotherapy, the median lethal dose (LD50) was equivalent regardless of the duration of exposure, and was independent of the exposure temperature. Taxanes showed a similar LD50 over the temperature range tested. CONCLUSIONS: In our study, hyperthermia does not increase the cytotoxic effects of taxanes, at least for the concentrations and durations tested.
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https://hal.univ-brest.fr/hal-00932168
Contributor : Ghislaine Calvez <>
Submitted on : Thursday, January 16, 2014 - 2:20:38 PM
Last modification on : Friday, June 19, 2020 - 3:08:39 AM

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Matthieu Muller, M. Chérel, Pierre-François Dupré, S. Gouard, M. Collet, et al.. The cytotoxic effect of combined hyperthermia and taxane chemotherapy on ovarian cancer cells: results of an in vitro study.. European Surgical Research, Karger, 2012, 48 (2), pp.55-63. ⟨10.1159/000333393⟩. ⟨hal-00932168⟩

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