HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Effectiveness and safety of saquinavir/ritonavir in HIV-infected pregnant women: INEMA cohort.

Abstract : OBJECTIVE: The authors had for aim to describe the effectiveness and the safety of a saquinavir/ritonavir (SQV/r) regimen, 1000/100mg twice daily, in HIV-infected pregnant patients. PATIENTS AND METHOD: We made a prospective and observational study of HIV positive female patients beginning or going on SQV/r antiretroviral treatment (ART) during pregnancy. RESULTS: Sixty-two patients were enrolled from July 2007 to June 2009 in 10 infectious diseases units in France. Thirty-six women (group 1) were ART naive on inclusion, 20 (group 2) had been previously treated and then switched to SQV/r, six (group 3) were treated with SQV/r before pregnancy. 58 patients delivered while on SQV/r regimen after a median pregnancy duration of 39 WA. Eighty percent had a viral load below 50 copies/mL and 93% below 400 copies/mL: respectively 77% and 93.5% in group 1, 83% and 89% in group 2, 83% and 100% in group 3. The median SQV minimum concentrations (C(min)) measured at the third trimester and at delivery were adequate, respectively 0.91 mg/L and 0.86 mg/L. Most women (52%) had a vaginal delivery; 12 (21%) had an elective caesarean section, for obstetrics factors in eight cases. None of the newborns were HIV-infected at 6 months of age (n = 59, one death at day 3). Only one severe adverse event occurred due to saquinavir (maternal grade 3 hepatotoxicity). CONCLUSION: SQV/r 1000/100mg twice daily seems to be effective and safe in HIV-infected pregnant women with adequate saquinavir C(min).
Document type :
Journal articles
Complete list of metadata

https://hal.univ-brest.fr/hal-00931634
Contributor : Ghislaine Calvez Connect in order to contact the contributor
Submitted on : Wednesday, January 15, 2014 - 3:19:35 PM
Last modification on : Wednesday, April 27, 2022 - 4:07:35 AM

Identifiers

Citation

Cécile Brunet, V. Reliquet, T. Jovelin, N. Venisse, Norbert Winer, et al.. Effectiveness and safety of saquinavir/ritonavir in HIV-infected pregnant women: INEMA cohort.. Med Mal Infect, 2012, 42 (9), pp.421-8. ⟨10.1016/j.medmal.2012.07.010⟩. ⟨hal-00931634⟩

Share

Metrics

Record views

40