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Cytotoxic effect of hyperthermia and chemotherapy with platinum salt on ovarian cancer cells: results of an in vitro study.

Abstract : PURPOSE: Hyperthermic intraperitoneal chemotherapy is continuously under evaluation in ovarian cancer. The purpose of the present study was to evaluate the effect of chemotherapy, drug concentration and temperature. MATERIALS AND METHODS: A human ovarian carcinoma cell line was used. The effect of hyperthermia combined with chemotherapy was analyzed. RESULTS: When hyperthermia was combined with chemotherapy, the 50% lethal dose (LD(50)) decreased with the duration of exposure. The effect of temperature was similar between 39 and 43 °C for a 30-min exposure. For a 60- to 90-min exposure, the LD(50) was equivalent between 38 and 43 °C. Beyond 40 °C, an increase in platinum salt concentration was necessary to obtain similar results according to the duration of exposure. CONCLUSIONS: The cytotoxic effect of the combination seemed to be potentiated and limited at 40 °C.
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https://hal.univ-brest.fr/hal-00931234
Contributor : Ghislaine Calvez Connect in order to contact the contributor
Submitted on : Wednesday, January 15, 2014 - 10:28:49 AM
Last modification on : Thursday, March 31, 2022 - 11:00:02 AM

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Matthieu Muller, Michel Chérel, Pierre-François Dupré, Sébastien Gouard, Michel Collet, et al.. Cytotoxic effect of hyperthermia and chemotherapy with platinum salt on ovarian cancer cells: results of an in vitro study.. European Surgical Research, Karger, 2011, 46 (3), pp.139-47. ⟨10.1159/000324395⟩. ⟨hal-00931234⟩

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