Cytotoxic effect of hyperthermia and chemotherapy with platinum salt on ovarian cancer cells: results of an in vitro study.

Matthieu Muller 1 Michel Chérel 2, 3 Pierre-François Dupré 1 Sébastien Gouard 3 Michel Collet 1, 4 Jean-Marc Classe 5
1 BREST - Gynéco-Obs - Service de Gynécologie-Obstétrique
2 Service de médecine nucléaire [Saint-Herblain]
3 CRCNA - Centre de Recherche en Cancérologie / Nantes - Angers
4 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
5 ICO Nantes - Institut de cancérologie de l'Ouest - Nantes
Abstract : PURPOSE: Hyperthermic intraperitoneal chemotherapy is continuously under evaluation in ovarian cancer. The purpose of the present study was to evaluate the effect of chemotherapy, drug concentration and temperature. MATERIALS AND METHODS: A human ovarian carcinoma cell line was used. The effect of hyperthermia combined with chemotherapy was analyzed. RESULTS: When hyperthermia was combined with chemotherapy, the 50% lethal dose (LD(50)) decreased with the duration of exposure. The effect of temperature was similar between 39 and 43 °C for a 30-min exposure. For a 60- to 90-min exposure, the LD(50) was equivalent between 38 and 43 °C. Beyond 40 °C, an increase in platinum salt concentration was necessary to obtain similar results according to the duration of exposure. CONCLUSIONS: The cytotoxic effect of the combination seemed to be potentiated and limited at 40 °C.
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Article dans une revue
European Surgical Research, Karger, 2011, 46 (3), pp.139-47. 〈10.1159/000324395〉
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http://hal.univ-brest.fr/hal-00931234
Contributeur : Ghislaine Calvez <>
Soumis le : mercredi 15 janvier 2014 - 10:28:49
Dernière modification le : jeudi 15 mars 2018 - 14:10:54

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Matthieu Muller, Michel Chérel, Pierre-François Dupré, Sébastien Gouard, Michel Collet, et al.. Cytotoxic effect of hyperthermia and chemotherapy with platinum salt on ovarian cancer cells: results of an in vitro study.. European Surgical Research, Karger, 2011, 46 (3), pp.139-47. 〈10.1159/000324395〉. 〈hal-00931234〉

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