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Mitral and aortic valvular disease associated with benfluorex use.

Abstract : Fenfluramine has been associated with an increased risk of pulmonary hypertension and valvular disease. Benfluorex is a fenfluramine derivative approved for the treatment of metabolic syndrome and type 2 diabetes mellitus. To date, only three isolated clinical cases of valvular disease and two recent case-control studies have been reported in patients exposed to benfluorex. Herein, the case is described of a patient with mitral and aortic valvular disease, with both echocardiographic and histopathological findings, who had been receiving benfluorex for several years, without any other etiology of valvular disease. The case is suggestive of toxic valvular lesions, similar to those observed previously during treatment with fenfluramine, pergolide, and cabergolide.
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Contributor : Ghislaine Calvez Connect in order to contact the contributor
Submitted on : Tuesday, January 14, 2014 - 3:53:54 PM
Last modification on : Thursday, March 31, 2022 - 11:00:02 AM


  • HAL Id : hal-00930669, version 1
  • PUBMED : 21714428



Yves Etienne, Yannick Jobic, Irene Frachon, Marjaneh Fatemi, Philippe Castellant, et al.. Mitral and aortic valvular disease associated with benfluorex use.. Journal of Heart Valve Disease, 2011, 20 (3), pp.348-50. ⟨hal-00930669⟩



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