Skip to Main content Skip to Navigation
Journal articles

Characterisation of severe obliterative bronchiolitis in rheumatoid arthritis.

Abstract : The characteristics of patients with rheumatoid arthritis (RA) who develop obliterative bronchiolitis characterised by severe airflow obstruction have been hitherto poorly investigated. A retrospective study of 25 patients with RA and functional evidence of obliterative bronchiolitis (forced expiratory volume in one second (FEV(1))/forced vital capacity (FVC) <50% and/or residual volume (RV)/total lung capacity (TLC) >140% predicted) was conducted. Patients (mean+/-SD age 64+/-11 yrs) included 17 never-smokers and eight ex-smokers (10.5+/-5.4 pack-yrs). The diagnosis of RA preceded respiratory symptoms in 88% of cases. Dyspnoea on exertion was present in all patients and bronchorrhea in 44%. High-resolution computed tomography findings included: bronchial wall thickening (96%), bronchiectasis (40%), mosaic pattern (40%), centrilobular emphysema (56%), and reticular and/or ground-glass opacities (32%). Pulmonary function tests showed: FEV(1) 41+/-12% pred, FEV(1)/FVC 49+/-14%, FVC 70+/-20% pred, RV 148+/-68% pred and RV/TLC 142+/-34% pred. Lung biopsy, available in nine patients, demonstrated constrictive, follicular and mixed bronchiolitis. Patients were followed for 48.2+/-49 months. Treatment was poorly effective. Chronic respiratory failure occurred in 40% of patients, and four patients died. Obliterative bronchiolitis associated with rheumatoid arthritis is a severe and under-recognised condition leading to respiratory failure and death in a high proportion of patients.
Document type :
Journal articles
Complete list of metadatas

https://hal.univ-brest.fr/hal-00922939
Contributor : Ghislaine Calvez <>
Submitted on : Tuesday, December 31, 2013 - 3:56:21 PM
Last modification on : Saturday, May 30, 2020 - 3:39:48 AM

Links full text

Identifiers

Collections

Citation

G. Devouassoux, V. Cottin, H. Lioté, E. Marchand, I. Frachon, et al.. Characterisation of severe obliterative bronchiolitis in rheumatoid arthritis.. European Respiratory Journal, European Respiratory Society, 2009, 33 (5), pp.1053-61. ⟨10.1183/09031936.00091608⟩. ⟨hal-00922939⟩

Share

Metrics

Record views

168