Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects.

Abstract : BACKGROUND: Epidemiologic studies indicate that chronic cough and sputum production are associated with increased mortality and disease progression in COPD subjects. Our objective was to identify features associated with chronic cough and sputum production in COPD subjects. METHODS: Cross-sectional analysis of data were obtained in a multicenter (17 university hospitals in France) cohort of COPD patients. The cohort comprised 433 COPD subjects (65 +/- 11 years; FEV(1), 50 +/- 20% predicted). Subjects with (n = 321) and without (n = 112) chronic cough and sputum production were compared. RESULTS: No significant difference was observed between groups for age, FEV(1), body mass index, and comorbidities. Subjects with chronic cough and sputum production had increased total mean numbers of exacerbations per patient per year (2.20 +/- 2.20 vs 0.97 +/- 1.19, respectively; p < 0.0001), moderate exacerbations (1.80 +/- 2.07 vs 0.66 +/- 0.85, respectively; p < 0.0001), and severe exacerbations requiring hospitalizations (0.43 +/- 0.95 vs 0.22 +/- 0.56, respectively; p < 0.02). The total number of exacerbations per patient per year was the only variable independently associated with chronic cough and sputum production. Frequent exacerbations (two or more per patient per year) occurred in 55% vs 22% of subjects, respectively, with and without chronic cough and sputum production (p < 0.0001). Chronic cough and sputum production and decreased FEV(1) were independently associated with an increased risk of frequent exacerbations and frequent hospitalizations. CONCLUSIONS: Chronic cough and sputum production are associated with frequent COPD exacerbations, including severe exacerbations requiring hospitalizations.
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Article dans une revue
Chest, American College of Chest Physicians, 2009, 135 (4), pp.975-82. 〈10.1378/chest.08-2062〉
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http://hal.univ-brest.fr/hal-00922932
Contributeur : Ghislaine Calvez <>
Soumis le : mardi 31 décembre 2013 - 15:27:14
Dernière modification le : lundi 12 mars 2018 - 13:48:01

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Pierre-Régis Burgel, Pascale Nesme-Meyer, Pascal Chanez, Denis Caillaud, Philippe Carré, et al.. Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects.. Chest, American College of Chest Physicians, 2009, 135 (4), pp.975-82. 〈10.1378/chest.08-2062〉. 〈hal-00922932〉

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