Detection of neovessels in atherosclerotic plaques of rabbits using dynamic contrast enhanced MRI and 18F-FDG PET.

Claudia Calcagno Jean-Christophe Cornily 1, 2 Fabien Hyafil 3 James H F Rudd Karen C Briley-Saebo Venkatesh Mani Gregg Goldschlager Josef Machac Valentin Fuster Zahi A Fayad
1 CHRU - Cardio - Département de Cardiologie
2 ORPHY (EA 4324) - Optimisation des régulations physiologiques
3 Service de cardiologie
Abstract : OBJECTIVE: The association of inflammatory cells and neovessels in atherosclerosis is considered a histological hallmark of high-risk active lesions. Therefore, the development and validation of noninvasive imaging techniques that allow for the detection of inflammation and neoangiogenesis in atherosclerosis would be of major clinical interest. Our aim was to test 2 techniques, black blood dynamic contrast enhanced MRI (DCE-MRI) and 18-fluorine-fluorodeoxyglucose (18F-FDG) PET, to quantify inflammation expressed as plaque neovessels content in a rabbit model of atherosclerosis. METHODS AND RESULTS: Atherosclerotic plaques were induced in the aorta of 10 rabbits by a combination of 2 endothelial abrasions and 4 months hyperlipidemic diet. Six rabbits underwent MRI during the injection of Gd-DTPA, whereas 4 rabbits were imaged after injection of 18F-FDG with PET. We found a positive correlation between neovessels count in atherosclerotic plaques and (1) Gd-DTPA uptake parameters evaluated by DCE-MRI (r=0.89, P=0.016) and (2) 18F-FDG uptake evaluated by PET (r=0.5, P=0.103 after clustered robust, Huber-White, standard errors analysis). CONCLUSIONS: DCE-MRI and 18F-FDG PET may allow for the evaluation of inflammation in atherosclerotic plaques of rabbits. These noninvasive imaging modalities could be proposed as clinical tools in the evaluation of lesion prognosis and monitoring of anti-angiogenic therapies.
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Article dans une revue
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2008, 28 (7), pp.1311-7. 〈10.1161/ATVBAHA.108.166173〉
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Contributeur : François Guerrero <>
Soumis le : dimanche 23 juin 2013 - 18:39:00
Dernière modification le : mardi 23 janvier 2018 - 11:56:14

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Claudia Calcagno, Jean-Christophe Cornily, Fabien Hyafil, James H F Rudd, Karen C Briley-Saebo, et al.. Detection of neovessels in atherosclerotic plaques of rabbits using dynamic contrast enhanced MRI and 18F-FDG PET.. Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2008, 28 (7), pp.1311-7. 〈10.1161/ATVBAHA.108.166173〉. 〈hal-00837630〉

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