TLR9 responses of B cells are repressed by intravenous immunoglobulin through the recruitment of phosphatase.

Jean-François Séité 1 Thomas Guerrier 1 Divi Cornec 1, 2 Christophe Jamin 1, 3 Pierre Youinou 1, 3 Sophie Hillion 1, 3
1 EA2216 - Immunologie et Pathologie
2 CHU - BREST - Rhumato - CHRU Brest - Service de Rhumatologie
3 Laboratoire d'Immunologie et Immunothérapie
Abstract : One way for intravenous Ig (IVIg) to affect responses of the B cells might be to operate through their TLR7 and TLR9. We confirm the ability of TLR agonists to induce CD25 expression in B cells. For this to occur, sialylated Fc-gamma of IgG included in the IVIg preparation are required. As a result, IVIg suppresses TLR-induced production of the proinflammatory IL-6, but not that of the anti-inflammatory IL-10. That is, IVIg mimics the effects of the MyD88 inhibitor. Finally, as we previously showed that IVIg induces CD22 to recruit the inhibitory SHP-1, we established that this enzyme was also involved in IVIg-induced inhibition of TLR9 signaling. This is the first report to demonstrate such a mechanism underlying the negative impact of IVIg on B lymphocytes.
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Journal of Autoimmunity, Elsevier, 2011, 37 (3), pp.190-7. 〈10.1016/j.jaut.2011.05.014〉
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Contributeur : Geneviève Michel <>
Soumis le : mardi 8 janvier 2013 - 11:28:26
Dernière modification le : mercredi 29 novembre 2017 - 14:53:52

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Jean-François Séité, Thomas Guerrier, Divi Cornec, Christophe Jamin, Pierre Youinou, et al.. TLR9 responses of B cells are repressed by intravenous immunoglobulin through the recruitment of phosphatase.. Journal of Autoimmunity, Elsevier, 2011, 37 (3), pp.190-7. 〈10.1016/j.jaut.2011.05.014〉. 〈hal-00771231〉

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