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TLR9 responses of B cells are repressed by intravenous immunoglobulin through the recruitment of phosphatase.

Abstract : One way for intravenous Ig (IVIg) to affect responses of the B cells might be to operate through their TLR7 and TLR9. We confirm the ability of TLR agonists to induce CD25 expression in B cells. For this to occur, sialylated Fc-gamma of IgG included in the IVIg preparation are required. As a result, IVIg suppresses TLR-induced production of the proinflammatory IL-6, but not that of the anti-inflammatory IL-10. That is, IVIg mimics the effects of the MyD88 inhibitor. Finally, as we previously showed that IVIg induces CD22 to recruit the inhibitory SHP-1, we established that this enzyme was also involved in IVIg-induced inhibition of TLR9 signaling. This is the first report to demonstrate such a mechanism underlying the negative impact of IVIg on B lymphocytes.
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https://hal.univ-brest.fr/hal-00771231
Contributor : Geneviève Michel <>
Submitted on : Tuesday, January 8, 2013 - 11:28:26 AM
Last modification on : Wednesday, November 29, 2017 - 2:53:52 PM

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Jean-François Séité, Thomas Guerrier, Divi Cornec, Christophe Jamin, Pierre Youinou, et al.. TLR9 responses of B cells are repressed by intravenous immunoglobulin through the recruitment of phosphatase.. Journal of Autoimmunity, Elsevier, 2011, 37 (3), pp.190-7. ⟨10.1016/j.jaut.2011.05.014⟩. ⟨hal-00771231⟩

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