Skip to Main content Skip to Navigation
Journal articles

Mesangial cell-specific antibodies are central to the pathogenesis of lupus nephritis.

Abstract : Not only is nephritis a common complaint in systemic lupus erythematosus, but it is also the most life-threatening complication of the disease. Anti-double-stranded DNA antibodies (Abs), which are found in up to 80% of these patients, might be nephritogenic per se. That is, they may cross-react with mesangial cell (MC) surface proteins, such as alpha-actinin and annexin A2, they may cross-react with mesangial matrix protein such as laminine and fibronectin, or they may recognize chromatin material previously deposited in the glomeruli. The consequence of the binding of anti-MC Abs may be their internalization, which results in activation and proliferation of these MCs. In turn, these activated MCs are suspected of promoting immune complex formation by sequestering and thereby protecting chromatin from degradation. The present paper will explain the mechanisms through which such autoAbs may initiate nephritis.
Document type :
Journal articles
Complete list of metadatas

Cited literature [59 references]  Display  Hide  Download

https://hal.univ-brest.fr/hal-00771079
Contributor : Geneviève Michel <>
Submitted on : Thursday, February 4, 2016 - 8:53:54 AM
Last modification on : Monday, December 18, 2017 - 2:40:13 PM
Long-term archiving on: : Saturday, November 12, 2016 - 7:22:15 AM

File

seret_et_al_CDI_2012.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Guillaume Seret, Yannick Le Meur, Yves Renaudineau, Pierre Youinou. Mesangial cell-specific antibodies are central to the pathogenesis of lupus nephritis.. Clinical and Developmental Immunology, Hindawi Publishing Corporation, 2012, 2012, pp.579670. ⟨10.1155/2012/579670⟩. ⟨hal-00771079⟩

Share

Metrics

Record views

181

Files downloads

711