Skip to Main content Skip to Navigation
New interface
Journal articles

Epigenetics and Sjögren's Syndrome

Abstract : There is growing evidence that epigenetics, the study of heritable changes in gene expression that do not involve mutations in the DNA itself, may play an essential role in autoimmune diseases (AID). In Sjögren's syndrome (SS), a chronic AID characterized by an epithelis of the exocrine glands, epigenetic studies have focused on three mechanisms: DNA methylation and its consequences including human endogenous retrovirus (HERV) expression; microRNA expression; and protein post-translational modifications associated with autoantibody production. Although in its infancy, comprehension of the epigenetic (dys)regulation in SS may help us to understand: why SS affects predominantly middle-aged women; why genetically predisposed individuals develop SS but not others; why flare-ups occur; why treatment responses differ between patients; and why some patients develop lymphoma. From these studies will arise a better comprehension of the pathophysiology of SS as well as development of new diagnostic and prognostic biomarkers, and novel therapeutics for prevention and perhaps early intervention.
Document type :
Journal articles
Complete list of metadata

Cited literature [22 references]  Display  Hide  Download
Contributor : Geneviève Michel Connect in order to contact the contributor
Submitted on : Saturday, December 2, 2017 - 6:38:23 PM
Last modification on : Monday, March 28, 2022 - 12:10:05 PM


Files produced by the author(s)




Christelle Le Dantec, Marie-Michèle Varin, Wesley H Brooks, Jacques-Olivier Pers, Pierre Youinou, et al.. Epigenetics and Sjögren's Syndrome. Current Pharmaceutical Biotechnology, 2012, 13 (10), pp.2046-53. ⟨10.2174/138920112802273326⟩. ⟨hal-00771074⟩



Record views


Files downloads