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TLR9 drives the development of transitional B cells towards the marginal zone pathway and promotes autoimmunity.

Abstract : Maturation of B cells depends on environmental stimuli. Peripheral immature B cells develop into follicular pathway when antigenic stimulation is combined with T cell signals. Here, we wished to identify stimuli contributing to the development into marginal zone B cells known to be involved in autoimmune response. We found that TLR9 stimulation of transitional B cells induces proliferation and specific maturation into CD24(-) CD38(+) CD21(high) CD23(low) IgM(high) IgD(low) and Notch2(high) B cells characteristics of marginal zone B cells. Terminal differentiation into antibody-secreting cell associated with isotype switch commitment is also triggered which leads to a striking production of autoantibodies. Interestingly, mature B cells do not differentiate into marginal zone pathway following TLR9 stimulation, nor do transitional B cells under antigenic and T cell combined signals. These results suggest that transitional B cells are specifically sensitive to TLR9 stimulation to produce autoreactive marginal zone B cells.
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https://hal.univ-brest.fr/hal-00770831
Contributor : Geneviève Michel Connect in order to contact the contributor
Submitted on : Monday, January 7, 2013 - 3:34:26 PM
Last modification on : Monday, March 28, 2022 - 12:10:04 PM

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Thomas Guerrier, Pierre Youinou, Jacques-Olivier Pers, Jamin Christophe. TLR9 drives the development of transitional B cells towards the marginal zone pathway and promotes autoimmunity.. Journal of Autoimmunity, Elsevier, 2012, 39 (3), pp.173-9. ⟨10.1016/j.jaut.2012.05.012⟩. ⟨hal-00770831⟩

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