The complexity of the BAFF TNF-family members: implications for autoimmunity - Université de Bretagne Occidentale Access content directly
Journal Articles Journal of Autoimmunity Year : 2012

The complexity of the BAFF TNF-family members: implications for autoimmunity

Ayan Lahiri
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Laetitia Le Pottier
Pierre Youinou
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  • PersonId : 919888

Abstract

The B-cell activating factor belonging to the tumor-necrosis factor family BAFF contributes to autoimmune disorders. As such, BAFF might become a therapeutic target. However, this molecule has pleiotropic effects that are as numerous as they are varied. The real effect of each form (spliced, glycosylated, membrane bound, soluble, homotrimerized, heterotrimerized, multimerized) has not been well characterized yet. Consequently, conflicting results, regarding the serum concentrations of BAFF or its functional effect, exist in literature. BAFF quantification based on ELISA commercial kits was indeed found to be inaccurate. The complexity of the various forms of BAFF will be reviewed by focusing on the different structural aspects of the molecule. These data have particular implications for autoimmunity, not only because of the role of these factors on B cell growth and survival, but also their influence on the onset and severity of several autoimmune diseases.

Domains

Immunology

Dates and versions

hal-00770190 , version 1 (04-01-2013)

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Cite

Ayan Lahiri, Pierre Pochard, Laetitia Le Pottier, Gabriel J. Tobon, Boutahar Bendaoud, et al.. The complexity of the BAFF TNF-family members: implications for autoimmunity. Journal of Autoimmunity, 2012, pp.189-198. ⟨10.1016/j.jaut.2012.05.009⟩. ⟨hal-00770190⟩

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