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CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte

R.A Mageed 1, * Soizic Garaud 2, 3 Taher E Taher 1 Kaushal Parikh 4 Jacques-Olivier Pers 3, 5 Christophe Jamin 3, 5 Yves Renaudineau 3, 5 Pierre Youinou 3, 5
* Corresponding author
1 William Harvey Research Institute, Barts and the London Medical School
2 Laboratory of Immunology
3 EA2216 - Immunologie et Pathologie
4 Laboratory of Experimental Medecine
5 Laboratory of Immunology
Abstract : CD5(+) B lymphocytes have distinct functional properties compared with B lymphocytes that lack CD5. However, it remains unclear if and how the CD5 molecule modulates B lymphocyte biology and responses. Our recent studies have revealed that CD5 promotes constitutive activation of multiple signaling pathways including extracellular signal-regulated kinases (ERK1/2), phosphatidylinositol 3-kinase (PI-3K)/mammalian target of rapamycin (mTOR) and calcineurin-NFAT signaling pathways. Further, changes in cytokine production including the production of IL-10 are related to the activation of the transcription factors NFAT2 and STAT3. All in all, these studies provide a framework for understanding how CD5 impacts B lymphocyte biology and responses.
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https://hal.univ-brest.fr/hal-00769761
Contributor : Geneviève Michel <>
Submitted on : Thursday, January 3, 2013 - 11:46:43 AM
Last modification on : Wednesday, November 29, 2017 - 2:53:50 PM

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R.A Mageed, Soizic Garaud, Taher E Taher, Kaushal Parikh, Jacques-Olivier Pers, et al.. CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte. Autoimmunity Reviews, Elsevier, 2012, pp.795-798. ⟨10.1016/j.autrev.2012.02.007⟩. ⟨hal-00769761⟩

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