 |
Journal articles
CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte
Abstract : CD5(+) B lymphocytes have distinct functional properties compared with B lymphocytes that lack CD5. However, it remains unclear if and how the CD5 molecule modulates B lymphocyte biology and responses. Our recent studies have revealed that CD5 promotes constitutive activation of multiple signaling pathways including extracellular signal-regulated kinases (ERK1/2), phosphatidylinositol 3-kinase (PI-3K)/mammalian target of rapamycin (mTOR) and calcineurin-NFAT signaling pathways. Further, changes in cytokine production including the production of IL-10 are related to the activation of the transcription factors NFAT2 and STAT3. All in all, these studies provide a framework for understanding how CD5 impacts B lymphocyte biology and responses.
https://hal.univ-brest.fr/hal-00769761
Contributor : Geneviève Michel Connect in order to contact the contributor
Submitted on : Thursday, January 3, 2013 - 11:46:43 AM
Last modification on : Monday, October 11, 2021 - 2:23:08 PM
Contributor : Geneviève Michel Connect in order to contact the contributor
Submitted on : Thursday, January 3, 2013 - 11:46:43 AM
Last modification on : Monday, October 11, 2021 - 2:23:08 PM