CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte - Université de Bretagne Occidentale Access content directly
Journal Articles Autoimmunity Reviews Year : 2012

CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte

Abstract

CD5(+) B lymphocytes have distinct functional properties compared with B lymphocytes that lack CD5. However, it remains unclear if and how the CD5 molecule modulates B lymphocyte biology and responses. Our recent studies have revealed that CD5 promotes constitutive activation of multiple signaling pathways including extracellular signal-regulated kinases (ERK1/2), phosphatidylinositol 3-kinase (PI-3K)/mammalian target of rapamycin (mTOR) and calcineurin-NFAT signaling pathways. Further, changes in cytokine production including the production of IL-10 are related to the activation of the transcription factors NFAT2 and STAT3. All in all, these studies provide a framework for understanding how CD5 impacts B lymphocyte biology and responses.

Domains

Immunology

Dates and versions

hal-00769761 , version 1 (03-01-2013)

Identifiers

Cite

R.A Mageed, Soizic Garaud, Taher E Taher, Kaushal Parikh, Jacques-Olivier Pers, et al.. CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte. Autoimmunity Reviews, 2012, pp.795-798. ⟨10.1016/j.autrev.2012.02.007⟩. ⟨hal-00769761⟩

Collections

UNIV-BREST IMMUNO
25 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More