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Prognostic value of fluorine-18 fluorodeoxyglucose positron-emission tomography imaging in patients with head and neck squamous cell carcinoma.

Abstract : BACKGROUND: High tumor uptake of fluorodeoxyglucose (FDG) is associated with an unfavorable outcome in patients with cancer. We evaluated FDG uptake as a prognostic factor in patients with head and neck squamous cell carcinoma. METHODS: Maximum standardized uptake values (SUVmax) of tumor, liver, and pulmonary artery were recorded. Ratios of SUVmax from tumor to liver (T/L) and from tumor to pulmonary artery (T/PA) were calculated for each patient. Clinical data, tumor, and SUVmax ratios were compared with disease-free survival (DFS) and overall survival (OS). RESULTS: Eighty-nine patients were included: 48 presented a local recurrent disease or distant metastases and 42 died. For both DFS and OS, tumor SUVmax value of 7 was the best cutoff value and 4 and 5 for T/L and T/PA ratios. Multivariate analysis confirmed the independent prognostic value of these 3 thresholds for DFS and OS. CONCLUSIONS: FDG uptake has a significant and independent relationship with recurrence and survival.
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https://hal.univ-brest.fr/hal-00759315
Contributor : Ghislaine Calvez <>
Submitted on : Friday, November 30, 2012 - 2:12:35 PM
Last modification on : Friday, November 30, 2012 - 2:12:35 PM

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Solène Querellou, Ronan Abgral, Pierre-Yves Le Roux, Emmanuel Nowak, Gérald Valette, et al.. Prognostic value of fluorine-18 fluorodeoxyglucose positron-emission tomography imaging in patients with head and neck squamous cell carcinoma.. Head and Neck, Wiley, 2012, 34 (4), pp.462-8. ⟨10.1002/hed.21765⟩. ⟨hal-00759315⟩

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