Prognostic value of fluorine-18 fluorodeoxyglucose positron-emission tomography imaging in patients with head and neck squamous cell carcinoma.

Solène Querellou 1 Ronan Abgral 1 Pierre-Yves Le Roux 1 Emmanuel Nowak 2 Gérald Valette 3 Gaël Potard 3 Alexandra Le Duc-Pennec 1 Marie-Béatrice Cavarec 1 Rémi Marianovski 3 Pierre-Yves Salaün 1, *
* Auteur correspondant
1 Department of Nuclear Medicine
2 CIC - Brest - Centre d'Investigation Clinique
3 Department of ORL
Abstract : BACKGROUND: High tumor uptake of fluorodeoxyglucose (FDG) is associated with an unfavorable outcome in patients with cancer. We evaluated FDG uptake as a prognostic factor in patients with head and neck squamous cell carcinoma. METHODS: Maximum standardized uptake values (SUVmax) of tumor, liver, and pulmonary artery were recorded. Ratios of SUVmax from tumor to liver (T/L) and from tumor to pulmonary artery (T/PA) were calculated for each patient. Clinical data, tumor, and SUVmax ratios were compared with disease-free survival (DFS) and overall survival (OS). RESULTS: Eighty-nine patients were included: 48 presented a local recurrent disease or distant metastases and 42 died. For both DFS and OS, tumor SUVmax value of 7 was the best cutoff value and 4 and 5 for T/L and T/PA ratios. Multivariate analysis confirmed the independent prognostic value of these 3 thresholds for DFS and OS. CONCLUSIONS: FDG uptake has a significant and independent relationship with recurrence and survival.
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Head and Neck, Wiley, 2012, 34 (4), pp.462-8. 〈10.1002/hed.21765〉
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http://hal.univ-brest.fr/hal-00759315
Contributeur : Ghislaine Calvez <>
Soumis le : vendredi 30 novembre 2012 - 14:12:35
Dernière modification le : vendredi 30 novembre 2012 - 14:12:35

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Solène Querellou, Ronan Abgral, Pierre-Yves Le Roux, Emmanuel Nowak, Gérald Valette, et al.. Prognostic value of fluorine-18 fluorodeoxyglucose positron-emission tomography imaging in patients with head and neck squamous cell carcinoma.. Head and Neck, Wiley, 2012, 34 (4), pp.462-8. 〈10.1002/hed.21765〉. 〈hal-00759315〉

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