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Midterm benefits of left univentricular pacing in patients with congestive heart failure.

Abstract : BACKGROUND: Resynchronization therapy by simultaneous pacing of the right and left ventricles has gained wide acceptance as a useful treatment for patients with severe congestive heart failure. Several short-term hemodynamic studies in humans and animals failed to demonstrate any benefit of biventricular pacing over left univentricular pacing, but long-term studies on this pacing mode are lacking. The objective of this study was to assess the outcome over a 1-year period of patients paced exclusively in the left ventricle. METHODS AND RESULTS: Clinical, angiographic, echocardiographic, and ergometric data were collected at baseline and after 12 months in 22 patients (age, 69.3+/-6.5 years) with NYHA class III or IV (10 patients), sinus rhythm, left bundle-branch block, and no bradycardia indication for pacing. After 12 months, compared with baseline values, NYHA class improved significantly by 40% (P<0.0001), 6-minute walk distance by 30% (P=0.01), peak VO2 by 26% (P=0.01), left ventricular end-diastolic diameter by 5% (P=0.02), ejection fraction by 22% (P=0.07), mitral regurgitation area by 40% (P=0.01), and norepinephrine level by 37% (P=0.04). CONCLUSIONS: In patients with severe congestive heart failure, sinus rhythm, and left bundle-branch block despite optimal pharmacological treatment, left univentricular pacing is feasible and results in significant midterm benefit in exercise tolerance and left ventricular function.
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Contributor : François Guerrero Connect in order to contact the contributor
Submitted on : Monday, November 19, 2012 - 10:08:03 PM
Last modification on : Monday, October 11, 2021 - 2:22:31 PM

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Jean-Jacques Blanc, Valérie Bertault-Valls, Marjaneh Fatemi, Martine Gilard, Pierre-Yves Pennec, et al.. Midterm benefits of left univentricular pacing in patients with congestive heart failure.. Circulation, 2004, 109 (14), pp.1741-4. ⟨10.1161/01.CIR.0000124479.89015.64⟩. ⟨hal-00753927⟩



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