Effect of baroreflex stimulation using phenylephrine injection on ST segment elevation and ventricular arrhythmia-inducibility in Brugada syndrome patients.

Vincent Probst 1 Philipe Mabo Frederic Sacher 2 Dominique Babuty Jacques Mansourati 3 Hervé Le Marec
1 ITX - unité de recherche de l'institut du thorax UMR1087 UMR6291
2 Hôpital Haut-Lévêque
3 ORPHY (EA 4324) - Optimisation des régulations physiologiques
Abstract : AIMS: Patients affected by Brugada syndrome (BrS) are at risk of sudden cardiac death specifically at rest, when vagal tone is high. The aim of our study was to assess whether a phenylephrine injection, which provokes a baroreflex stimulation, could induce modification of the ST segment elevation and ventricular arrhythmias. METHODS AND RESULTS: Baroreflex test was performed with the administration of phenylephrine (2 microg/kg) to four highly symptomatic patients in a setting fully equipped for cardiac resuscitation. Phenylephrine injection induced a deep vagal stimulation with a decrease in the mean heart rate from 75 +/- 7 to 50 +/- 8 bpm and an increase in the mean systolic blood pressure from 141 +/- 14 to 204 +/- 46 mmHg. ST segment elevation was not modified and no ventricular arrhythmias were induced during the test. CONCLUSION: Although phenylephrine injection induced a major alpha-adrenergic vasoconstriction followed by an arterial baroreflex, this test failed to provoke ventricular arrhythmias or modification of the ST segment elevation in BrS patients.
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EP-Europace, Oxford University Press (OUP): Policy B, 2009, 11 (3), pp.382-4. 〈10.1093/europace/eun365〉
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http://hal.univ-brest.fr/hal-00750426
Contributeur : François Guerrero <>
Soumis le : vendredi 9 novembre 2012 - 22:52:42
Dernière modification le : lundi 25 juin 2018 - 09:33:32

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Vincent Probst, Philipe Mabo, Frederic Sacher, Dominique Babuty, Jacques Mansourati, et al.. Effect of baroreflex stimulation using phenylephrine injection on ST segment elevation and ventricular arrhythmia-inducibility in Brugada syndrome patients.. EP-Europace, Oxford University Press (OUP): Policy B, 2009, 11 (3), pp.382-4. 〈10.1093/europace/eun365〉. 〈hal-00750426〉

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