Central inhibitory effect of adenosine deaminase on carotid blood flow increase at high pressure. - Université de Bretagne Occidentale Access content directly
Journal Articles Physiology & behavior Year : 1996

Central inhibitory effect of adenosine deaminase on carotid blood flow increase at high pressure.

H. Burnet
  • Function : Author

Abstract

Carotid blood flow in rats was measured by implanted transit-time ultrasonic flowprobes throughout hyperbaric experiments conducted up to 70 bar (7 MPa) with a helium-oxygen hyperoxic (PO2 = 400 mbar) mixture. Before the hyperbaric experiment, an intracerebroventricular (ICV) injection of phosphate saline-buffered solution (PBS) or adenosine deaminase (ADA, 100 U.ml-1) in PBS was performed. Throughout the hyperbaric experiment carotid blood flow increased with ambiant pressure in PBS-treated rats. Conversely, the increase in carotid blood flow was attenuated by ADA treatment. These results suggest that the increase in carotid blood flow at high ambiant pressure could result from an increase of adenosine concentration in the rat brain.
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  • HAL Id : hal-00743432 , version 1
  • PUBMED : 8838607

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François Guerrero, H. Burnet. Central inhibitory effect of adenosine deaminase on carotid blood flow increase at high pressure.. Physiology & behavior, 1996, 59 (2), pp.283-6. ⟨hal-00743432⟩
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