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The DESIR cohort: a 10-year follow-up of early inflammatory back pain in France: study design and baseline characteristics of the 708 recruited patients.

Maxime Dougados 1, * Maria-Antonietta d'Agostino 2 Joëlle Benessiano 3 Francis Berenbaum Maxime Breban 2 Pascal Claudepierre 4, 5 Bernard Combe 6 Patricia Dargent-Molina 7 Jean-Pierre Daurès 8 Bruno Fautrel 9 Antoine Feydy 10 Philippe Goupille 11 Véronique Leblanc Isabelle Logeart 12 Thao Pham 13 Pascal Richette 14 Christian Roux 15 Martin Rudwaleit Alain Saraux 16, 17, 18 Jean-Marc Treluyer 19, 20 Désirée van Der Heijde 21 Daniel Wendling 22 
Abstract : OBJECTIVES: The French Society of Rheumatology has initiated a large national multicenter, longitudinal, prospective follow-up of patients presenting with early inflammatory back pain in order to set up a database to facilitate several investigations on diagnosis, prognosis, epidemiology, pathogenesis and medico-economics in the field of early inflammatory back pain and spondyloarthritis. METHODS: Patients were recruited if they had inflammatory back pain of more than 3 months and less than 3 years. Patients will be followed every 6 months during the first 2 years then every year during at least 5years. Apart from information collected on a Case Report Form (demographics, disease activity, severity, co-morbidities, socio-economics, treatments, radiological and MRI evaluation of the spine and the pelvis according to the local investigators, and for some centers bone densitometry and ultrasonography of entheses), the digital X-rays and MRI of the spine and pelvis are stored using a specific software (Carestream) and the biological samples (DNA, RNA, sera, urines) are centralized at the Biological Resources Center (Bichat Hospital). RESULTS: The recruitment period of the 708 patients (mean age: 34±9years, female 54%, HLA-B27 positive: 57%) in the 25 centers was 26 months (from December 2007 to April 2010). The modified New York criteria, Amor criteria, ESSG criteria and axial ASAS criteria were fulfilled by 26%, 77%, 76% and 67% of the patients at entry, respectively. A history or current symptoms suggestive of peripheral arthritis, acute anterior uveitis and inflammatory bowel disease were observed in 21%, 9% and 4% of the patients, respectively. The disease was active (BASDAI: 45±20) despite an NSAID intake in 66% of the patients. CONCLUSION: This large cohort should facilitate the conduct of researches in different areas (clinical, medico-economics, translational) in order to improve our knowledge on the pathogenesis and natural history of axial spondyloarthritis.
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Submitted on : Tuesday, September 11, 2012 - 12:12:52 PM
Last modification on : Saturday, October 29, 2022 - 3:21:10 AM



Maxime Dougados, Maria-Antonietta d'Agostino, Joëlle Benessiano, Francis Berenbaum, Maxime Breban, et al.. The DESIR cohort: a 10-year follow-up of early inflammatory back pain in France: study design and baseline characteristics of the 708 recruited patients.. Joint Bone Spine, 2011, 78 (6), pp.598-603. ⟨10.1016/j.jbspin.2011.01.013⟩. ⟨hal-00730858⟩



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