HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Evaluation of a new, rapid, and quantitative D-Dimer test in patients with suspected pulmonary embolism.

Abstract : Previous studies have suggested the utility of D-Dimer ELISA assays in eliminating a diagnosis of pulmonary embolism (PE). Our objectives were to evaluate the performance of a new, rapid, quantitative, and automated Liatest D-Dimer Assay in patients with suspected PE. Three hundred eighty-six consecutive patients referred to our institution between March 1992 and December 1996 for clinically suspected PE, with recent clinical signs not exceeding 1 wk, were included in this study. Diagnosis of PE was based on clinical evaluation, radionuclide lung imaging, lower limb examination, and, when required, pulmonary angiography. D-Dimer performances, for both Liatest D-Dimer and standard D-Dimer ELISA (Asserachrom DDi), assays, were assessed at the end of the study. Among the 386 patients tested, 146 (37.8%) were classified as PE-positive. Liatest D-Dimer assay had a 100% sensitivity (95% confidence interval, 97 to 100%) and a negative predictive value of 100% (95% confidence interval, 94 to 100%). A normal result, below the cutoff of 500 ng/ml, occurred in 83 of the 386 (21%) patients. There was a strong agreement between Liatest D-Dimer and Asserachrom DDi analyses. These findings suggest that this rapid, quantitative, and automated D-Dimer assay provides a useful diagnostic tool for the clinician with regard to exclusion of PE.
Document type :
Journal articles
Complete list of metadata

https://hal.univ-brest.fr/hal-00722367
Contributor : Ghislaine Calvez Connect in order to contact the contributor
Submitted on : Wednesday, August 1, 2012 - 1:49:48 PM
Last modification on : Thursday, March 31, 2022 - 11:00:02 AM

Identifiers

  • HAL Id : hal-00722367, version 1
  • PUBMED : 9655708

Collections

Citation

Emmanuel Oger, Christophe Leroyer, Luc Bressollette, Michel Nonent, Emmanuelle Le Moigne, et al.. Evaluation of a new, rapid, and quantitative D-Dimer test in patients with suspected pulmonary embolism.. American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 1998, 158 (1), pp.65-70. ⟨hal-00722367⟩

Share

Metrics

Record views

55