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Evaluation of a new, rapid, and quantitative D-Dimer test in patients with suspected pulmonary embolism.

Abstract : Previous studies have suggested the utility of D-Dimer ELISA assays in eliminating a diagnosis of pulmonary embolism (PE). Our objectives were to evaluate the performance of a new, rapid, quantitative, and automated Liatest D-Dimer Assay in patients with suspected PE. Three hundred eighty-six consecutive patients referred to our institution between March 1992 and December 1996 for clinically suspected PE, with recent clinical signs not exceeding 1 wk, were included in this study. Diagnosis of PE was based on clinical evaluation, radionuclide lung imaging, lower limb examination, and, when required, pulmonary angiography. D-Dimer performances, for both Liatest D-Dimer and standard D-Dimer ELISA (Asserachrom DDi), assays, were assessed at the end of the study. Among the 386 patients tested, 146 (37.8%) were classified as PE-positive. Liatest D-Dimer assay had a 100% sensitivity (95% confidence interval, 97 to 100%) and a negative predictive value of 100% (95% confidence interval, 94 to 100%). A normal result, below the cutoff of 500 ng/ml, occurred in 83 of the 386 (21%) patients. There was a strong agreement between Liatest D-Dimer and Asserachrom DDi analyses. These findings suggest that this rapid, quantitative, and automated D-Dimer assay provides a useful diagnostic tool for the clinician with regard to exclusion of PE.
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https://hal.univ-brest.fr/hal-00722367
Contributor : Ghislaine Calvez <>
Submitted on : Wednesday, August 1, 2012 - 1:49:48 PM
Last modification on : Thursday, November 29, 2018 - 4:09:26 PM

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  • HAL Id : hal-00722367, version 1
  • PUBMED : 9655708

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Emmanuel Oger, Christophe Leroyer, Luc Bressollette, Michel Nonent, Emmanuelle Le Moigne, et al.. Evaluation of a new, rapid, and quantitative D-Dimer test in patients with suspected pulmonary embolism.. American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 1998, 158 (1), pp.65-70. ⟨hal-00722367⟩

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