Early versus delayed introduction of oral vitamin K antagonists in combination with low-molecular-weight heparin in the treatment of deep vein thrombosis. a randomized clinical trial. The ANTENOX Study Group.

Christophe Leroyer 1, 2 Luc Bressollette 2, 1 Emmanuel Oger 2 Jacques Mansourati 3, 4 Catherine Chèze-Le Rest 5 Michel Nonent 2, 6 Andréa Buchmuller B. Tardy 7 Hervé Decousus Florence Parent 8 G. Simonneau 9 K. Juste Patrick Ill Jean-François Abgrall 10 Jean Clavier 1 Dominique Mottier 2
1 DMIP - Brest - Département de Médecine Interne et Pneumologie [Brest]
2 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
3 BREST - Cardio - Service de Cardiologie
4 ORPHY (EA 4324) - Optimisation des régulations physiologiques
5 Service de médecine nucléaire [Brest]
6 DR - Brest - Département de radiologie [Brest]
7 GRT (EA 3065) - Groupe de recherche sur la thrombose
8 Service de pneumologie [Béclère]
9 UPRES - EA2705 - Centre National de Référence de l'Hypertension Artérielle Pulmonaire
10 CHU-Brest-Hemato - CHRU Brest - Service d'Hématologie
Abstract : Objective: To compare oral anticoagulant treatment (fluindione) started on either the 1st or the 10th day of a low-molecular-weight heparin (enoxaparin) treatment for deep vein thrombosis confirmed by venography. Design: An open, multicenter, randomized study in two parallel treatment groups. Interventions: All patients received enoxaparin, 1 mg/kg s.c. twice daily, and oral fluindione, 20 mg once daily, either beginning on day 1 or on day 10 of the enoxaparin treatment. Enoxaparin was discontinued once the international normalized ratio under fluindione was stable between 2.0 and 3.0 over 2 days. Fluindione treatment was maintained during a 3-month follow-up period. Outcome Measurements: Specific examinations (venography and/or V/Q lung scanning and/or angiography) were performed only in the event of a clinically suspected recurrence of venous thromboembolism during the 3-month follow-up period. All cases were blindly assessed by an independent Reading Committee. Results: A clinically suspected venous thromboembolism was confirmed by objective tests in 1 of 223 patients (group of delayed introduction of fluindione; n = 111). Equivalence was demonstrated between the two treatment schedules (p < 0.0001) for a maximal difference of 10% (90% confidence interval: -2.42 to 0.58). The mean duration of hospitalization was significantly reduced (p = 0.0001) in the group with early introduction of fluindione. The incidence of hemorrhage was comparable between the two treatment groups. Conclusion: Early and delayed introduction of oral anticoagulant treatment in association with subcutaneous enoxaparin in patients with deep vein thrombosis was shown to be equivalent in preventing the recurrence of venous thromboembolism. In patients with early introduction of oral anticoagulant, hospitalization was significantly reduced.
Type de document :
Article dans une revue
Haemostasis, S Karger AG, 1998, 28 (2), pp.70-7
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http://hal.univ-brest.fr/hal-00722362
Contributeur : Ghislaine Calvez <>
Soumis le : mercredi 1 août 2012 - 13:43:44
Dernière modification le : mercredi 10 janvier 2018 - 14:42:02

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  • HAL Id : hal-00722362, version 1
  • PUBMED : 10087431

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UNIV-ST-ETIENNE | GETBO | UNIV-BREST

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Christophe Leroyer, Luc Bressollette, Emmanuel Oger, Jacques Mansourati, Catherine Chèze-Le Rest, et al.. Early versus delayed introduction of oral vitamin K antagonists in combination with low-molecular-weight heparin in the treatment of deep vein thrombosis. a randomized clinical trial. The ANTENOX Study Group.. Haemostasis, S Karger AG, 1998, 28 (2), pp.70-7. 〈hal-00722362〉

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