Prevention of venous thrombosis in patients with acute intracerebral hemorrhage.

Karine Lacut 1, 2, * Luc Bressollette 3 Grégoire Le Gal 1, 2 Edith Etienne Anne De Tinteniac Anne Renault François Rouhart 4 G. Besson Jean-François Garcia Dominique Mottier 2, 1 Emmanuel Oger Non Renseigné
* Auteur correspondant
1 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
2 CIC - Brest - Centre d'Investigation Clinique
3 DMIP - Brest - Département de Médecine Interne et Pneumologie [Brest]
4 Service de Neurologie [Brest]
Abstract : OBJECTIVE: To assess intermittent pneumatic compression (IPC) in the prevention of venous thromboembolism (VTE). METHODS: The authors randomly allocated patients with a documented intracerebral hemorrhage (ICH) to elastic stockings (ES) alone or combined with IPC. The primary outcome was a combined criteria assessed at day 10: a symptomatic and well-documented VTE, or a death arising before day 10 and related to pulmonary embolism (PE), or an asymptomatic deep vein thrombosis (DVT) of the lower limbs detected by compression ultrasonography (CUS). Outcome assessment was blinded. RESULTS: One hundred fifty-one patients were randomized; 133 (88%) patients were evaluated at day 10. No clinical suspicion of VTE arose before day 10. Fourteen patients died before having a CUS but no death was definitely related to PE. Fourteen asymptomatic DVT were detected by CUS: three (4.7%) in the ES + IPC group (all distal) and 11 (15.9%) in the ES group (three proximal and eight distal). ES combined with IPC is associated with a reduced risk of asymptomatic DVT compared to ES alone: relative risk, 0.29 (95% CI 0.08 to 1.00). CONCLUSIONS: Asymptomatic deep vein thrombosis (DVT) was detected at day 10 in 15.9% of patients wearing elastic stockings alone. Intermittent pneumatic compression significantly decreased the occurrence of asymptomatic DVT for patients with intracerebral hemorrhage.
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Article dans une revue
Neurology, American Academy of Neurology, 2005, 65 (6), pp.865-9. 〈10.1212/01.wnl.0000176073.80532.a2〉
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http://hal.univ-brest.fr/hal-00722075
Contributeur : Ghislaine Calvez <>
Soumis le : mardi 31 juillet 2012 - 16:26:08
Dernière modification le : mercredi 10 janvier 2018 - 14:42:02

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UNIV-BREST | GETBO

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Karine Lacut, Luc Bressollette, Grégoire Le Gal, Edith Etienne, Anne De Tinteniac, et al.. Prevention of venous thrombosis in patients with acute intracerebral hemorrhage.. Neurology, American Academy of Neurology, 2005, 65 (6), pp.865-9. 〈10.1212/01.wnl.0000176073.80532.a2〉. 〈hal-00722075〉

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