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Journal articles
Risk of recurrent venous thromboembolism after a first oestrogen-associated episode. Data from the REVERSE cohort study.
Grégoire Le Gal
1, 2
Michael J Kovacs
3
Marc Carrier
4
Kimberley Do
Susan R Kahn
5
Philip S Wells
6, 7
David A Anderson
8
Isabelle Chagnon
9
Susan Solymoss
Mark Crowther
10
Marc Righini
11
Karine Lacut
1, 2
Richard H White
Linda Vickars
Marc Rodger
Susan R Kahn 5
Author
Philip S Wells 6, 7
Author
David A Anderson 8
Author
Isabelle Chagnon 9
Author
1
GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale (CHU de la Cavale Blanche Département de médecine interne et pneumologie 29609 BREST - France)
- UBO - Université de Brest : EA3878 (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
- IBSAM - Institut Brestois Santé Agro Matière (Université de Brest- UBO
29238 Brest - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
2
CIC - Brest - Centre d'Investigation Clinique (CHU de la Cavale Blanche 29609 Brest - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : CIC502 (101, rue de Tolbiac, 75013 Paris - France)
3
MJK - Division of Hematology (Division of Hematology Department of Medicine University of Western Ontario, London - Canada)
- UWO - University of Western Ontario (1151 Richmond St, London, ON, N6A 3K7, Canada - Canada)
4
Clinical Epidemiology Unit (Ottawa Hospital Research Institute - Canada)
- Ottawa (France)
- The Ottawa Hospital (France)
5
Department of Medecine [Montréal] (McGill University McIntyre Medical Building, 3655 Sir William Osler Montreal, Quebec H3G 1Y6 - Canada)
- McGill University = Université McGill [Montréal, Canada] (845, rue Sherbrooke O. Montréal (Québec) Canada H3A 0G4 - Canada)
7
Thrombosis Program (Division of Hematology Department of Medicine - France)
- University of Ottawa [Ottawa] (75 Laurier Avenue East, Ottawa, ON K1N 6N5 - Canada)
8
Department of Medicine (HALIFAX - Canada)
- Dalhousie University [Halifax] ( 6299 South St, Halifax, NS B3H 4R2 - Canada)
9
Department of Medicine (Hôpital du Sacré Coeur de Montréal - France)
- University of Montreal (France)
10
Department of Medicine (Michael G. DeGroote School of Medicine Hamilton - France)
- McMaster University [Hamilton, Ontario] (1280 Main Street West Hamilton, Ontario L8S 4L8 - Canada)
11
MR - Service d'angiologie et d'hémostase (Département de médecine Hôpital universitaire de Genève 24, rue Micheli-du-Crest 1211 Genève 14 - Switzerland)
- Hôpital Universitaire de Genève (Switzerland)
Abstract : The use of exogenous oestrogen in women with otherwise unprovoked venous thromboembolism (VTE) could be considered sufficient explanation to classify VTE as provoked if the risk of recurrent VTE after 3-6 months of anticoagulant treatment is similar to the risk of recurrent VTE observed after a surgery or prolonged immobilisation. Our objective was to assess the risk of recurrent VTE in women after a first unprovoked episode on oestrogen. The REVERSE study is a cohort study of patients with a first unprovoked VTE treated with anticoagulant treatment for 5-7 months. The risk of recurrent VTE during follow-up was compared between women users and non users of oestrogen at the time of index VTE. Among the 646 patients included, 314 were women, of them 67 were current users of oestrogen at the time of their VTE: 49 were on oral contraceptives and 18 on post-menopausal hormone replacement therapy (HRT). No significant association was found between oestrogen exposure, either oral contraceptives or HRT, and a lower risk of recurrent VTE after adjustment for age, or analysis restricted to women in the same age range as oestrogen contraceptives and HRT users, respectively. The risk of recurrent VTE is low in women after a first otherwise unprovoked oestrogen-associated VTE. However, this risk is not significantly lower than in women whose VTE was not related to oestrogen use.
Document type :
Journal articles
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Complete list of metadata
https://hal.univ-brest.fr/hal-00722011
Contributor : Ghislaine Calvez Connect in order to contact the contributor
Submitted on : Tuesday, July 31, 2012 - 1:31:13 PM
Last modification on : Monday, October 11, 2021 - 2:23:06 PM
Contributor : Ghislaine Calvez Connect in order to contact the contributor
Submitted on : Tuesday, July 31, 2012 - 1:31:13 PM
Last modification on : Monday, October 11, 2021 - 2:23:06 PM
Identifiers
- HAL Id : hal-00722011, version 1
- DOI : 10.1160/TH09-10-0685
- PUBMED : 20539910
Collections
UNIV-BREST | GETBO | IBSAM
Citation
Grégoire Le Gal, Michael J Kovacs, Marc Carrier, Kimberley Do, Susan R Kahn, et al.. Risk of recurrent venous thromboembolism after a first oestrogen-associated episode. Data from the REVERSE cohort study.. Thrombosis and Haemostasis, Schattauer, 2010, 104 (3), pp.498-503. ⟨10.1160/TH09-10-0685⟩. ⟨hal-00722011⟩
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